Details of the Target

General Information of Target

Target ID LDTP08283
Target Name Immunoglobulin-like and fibronectin type III domain-containing protein 1 (IGFN1)
Gene Name IGFN1
Gene ID 91156
Synonyms
EEF1A2BP1; KYIP1; Immunoglobulin-like and fibronectin type III domain-containing protein 1; EEF1A2-binding protein 1; KY-interacting protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGKLRKSHIPGVSIWQLVEEIPEGCSTPDFEQKPVTSALPEGKNAVFRAVVCGEPRPEV
RWQNSKGDLSDSSKYKISSSPGSKEHVLQINKLTGEDTDLYRCTAVNAYGEAACSVRLTV
IEVGFRKNRKRHREPQEDLRKELMDFRKLLKKRAPPAPKKKMDLEQIWQLLMTADRKDYE
KICLKYGIVDYRGMLRRLQEMKKEQEDKMAQYINTISSLRHIRVTKDGNAKFDLELDLKD
SQSKIYLYKDGEMIPYGFNNQTKHCLRRLGKRYEFQIQDLRPEDSGIYQVKVEDAVVFST
ELEASAIPPRVVVPLAETHCEEQGDAVFECTLSSPCPSAAWHFRHRLLHPSDKYEVYVSP
DGLTHRLVVRGARFSDMGPYSLGTGLYTSSAWLVVEAGKDKDLQSTSADHKLQSRRSGKD
GRLDIYGERRDATRSSTSRYKPGTGSFSKDAQGPMGHFSQGLADMEVQPGEAATLSCTLT
SDLGPGTWFKDGVKLTTQDGVIFKQDGLVHSLFITHVQGTQAGRYTFVAGDQQSEATLTV
QDSPTIAPDVTEKLREPLVVKAGKPVIVKIPFQSHLPIQAAWRKDGAEVVGSSDREAQVD
LGDGYTRLCLPSAGRKDCGQYSVTLRSEGGSVQAELTLQVIDKPDPPQGPMEVQDCHRAG
VCLRWRPPRDNGGRTVECYVVERRQAGRSTWLKVGEAPADSTTFTDAHVEPGRKYTFRVR
AVTSEGAGEALESEEILVAPEALPKAPSAPAILSASSQGITLTWTAPRGPGSAHILGYLI
ERRKKGSNTWTAVNDQPVPERRWTVADVRQGCQYEFRVTAVAPSGPGEPGPPSDAVFARD
PMRPPGLVRNLQVTDRSNTSITLSWAGPDTQEGDEAQGYVVELCSSDSLQWLPCHVGTVP
VTTYTAKGLRPGEGYFVRVTAVNEGGQSQPSALDTLVQAMPVTVCPKFLVDSSTKDLLTV
KVGDTVRVPVSFEAMPMPEVTWLKDGLPLPKRSVTVTKDGLTQLLIPVAGLSDSGLYTVV
LRTLQGKEVAHSFRIRVAACPQAPGPIHLQENVPGTVTAEWEPSPDEAQDVPLHYAVFTR
SSAHGPWHEAADRIHTNRFTLLGILPGHEYHFRVVAKNELGASKPSDTSQPWCIPRQRDR
FTVKAPCYREPDLSQKPRFLVGLRSHLLPQGCECCMSCAVQGSPRPHVTWFKNDRSLEGN
PAVYSTDLLGVCSLTIPSVSPKDSGEYKAVAENTLGQAVSTATLIVIEPST
Target Bioclass
Immunoglobulin
Subcellular location
Nucleus
Uniprot ID
Q86VF2
Ensemble ID
ENST00000295591.12
HGNC ID
HGNC:24607

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C477(1.66)  LDD2157  [1]
CY4
 Probe Info  		N.A.  LDD0247  [2]
WYneN
 Probe Info  		N.A.  LDD0021  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Putative hydrolase DDAH2 (DDAH2) DDAH family O95865
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transcription factor
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-D3 (HOXD3) Antp homeobox family P31249
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Golgin-45 (BLZF1) . Q9H2G9
Homeobox protein MOX-2 (MEOX2) . P50222
LIM/homeobox protein Lhx9 (LHX9) . Q9NQ69
Myoblast determination protein 1 (MYOD1) . P15172
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 39 (KRT39) Intermediate filament family Q6A163
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Proline-rich protein 23B (PRR23B) PRR23 family Q6ZRT6
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
NHL-repeat-containing protein 4 (NHLRC4) . P0CG21
SERTA domain-containing protein 2 (SERTAD2) . Q14140
Sperm-associated antigen 5 (SPAG5) . Q96R06
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764