Details of the Target

General Information of Target

Target ID LDTP08131
Target Name Allergin-1 (MILR1)
Gene Name MILR1
Gene ID 284021
Synonyms
C17orf60; MCA32; Allergin-1; Allergy inhibitory receptor 1; Mast cell antigen 32; MCA-32; Mast cell immunoglobulin-like receptor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWSHLNRLLFWSIFSSVTCRKAVLDCEAMKTNEFPSPCLDSKTKVVMKGQNVSMFCSHKN
KSLQITYSLFRRKTHLGTQDGKGEPAIFNLSITEAHESGPYKCKAQVTSCSKYSRDFSFT
IVDPVTSPVLNIMVIQTETDRHITLHCLSVNGSLPINYTFFENHVAISPAISKYDREPAE
FNLTKKNPGEEEEYRCEAKNRLPNYATYSHPVTMPSTGGDSCPFCLKLLLPGLLLLLVVI
ILILAFWVLPKYKTRKAMRNNVPRDRGDTAMEVGIYANILEKQAKEESVPEVGSRPCVST
AQDEAKHSQELQYATPVFQEVAPREQEACDSYKSGYVYSELNF
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction.
Uniprot ID
Q7Z6M3
Ensemble ID
ENST00000612535.4
HGNC ID
HGNC:27570

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.Q319Ter .
HT115 SNV: p.W247C .
P31FUJ SNV: p.A170D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C110(2.98)  LDD3325  [1]
IA-alkyne
 Probe Info  		C297(2.43)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C329(2.29); C297(1.82)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C329(2.18)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C329(1.10); C297(0.58)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C329(1.16); C297(1.45)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C329(0.84); C297(1.14)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C297(1.30)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C329(1.54); C297(1.26)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C329(1.14); C297(1.20)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C329(1.04); C297(1.19)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C329(1.03); C297(1.31)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C329(0.78); C297(0.81)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C329(1.27); C297(1.62)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C329(1.14); C297(1.15)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C329(1.68); C297(2.22)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C329(1.50); C297(1.63)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C329(1.18); C297(1.19)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C329(0.78); C297(1.19)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C329(1.08); C297(1.49)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C329(1.42); C297(1.62)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C329(1.02); C297(1.42)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C329(1.68); C297(1.80)  LDD2188  [2]
 LDCM0022  KB02 Ramos C297(2.43)  LDD2182  [2]
 LDCM0023  KB03 Ramos C329(0.84); C297(1.22)  LDD2183  [2]
 LDCM0024  KB05 UACC257 C110(2.98)  LDD3325  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578