Details of the Target

General Information of Target

Target ID LDTP07960
Target Name Docking protein 3 (DOK3)
Gene Name DOK3
Gene ID 79930
Synonyms
Docking protein 3; Downstream of tyrosine kinase 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPL
ETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPG
RRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFP
GTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVL
GPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLC
RAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEP
GPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEG
PGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVT
LLSRERRKGPAPCDRP
Target Bioclass
Other
Family
DOK family, Type A subfamily
Subcellular location
Cytoplasm
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
Uniprot ID
Q7L591
Ensemble ID
ENST00000312943.10
HGNC ID
HGNC:24583

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C493(2.10)  LDD3334  [1]
IA-alkyne
 Probe Info  		C493(1.32); C323(2.26); C230(0.46)  LDD2182  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C493(1.34); C323(1.39); C230(0.80)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C493(1.76); C323(1.41); C230(0.44)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C493(0.03); C323(0.10); C230(0.61)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C493(0.88); C323(1.12); C230(0.38)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C493(0.86); C323(1.05); C230(0.80)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C493(0.66); C323(0.92); C230(0.52)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C493(0.84); C323(0.96); C230(0.49)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C493(0.88); C323(0.92); C230(0.61)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C493(1.24); C323(1.59); C230(0.42)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C493(0.85); C323(1.37); C230(0.72)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C493(1.00); C323(0.68); C230(1.01)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C493(1.19); C323(1.76); C230(0.79)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C493(0.83); C323(0.88); C230(0.70)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C493(1.23); C323(2.08); C230(0.44)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C493(1.03); C323(1.16); C230(0.68)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C493(1.09); C323(0.80); C230(1.24)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C493(0.92); C323(1.36); C230(0.63)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C493(1.08); C323(0.77); C230(1.10)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C493(1.75); C323(1.39); C230(0.84)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C493(1.75); C323(1.31); C230(0.48)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C493(1.02); C323(0.97); C230(0.46)  LDD2188  [2]
 LDCM0022  KB02 Ramos C493(1.32); C323(2.26); C230(0.46)  LDD2182  [2]
 LDCM0023  KB03 Ramos C493(0.84); C323(0.97); C230(0.56)  LDD2183  [2]
 LDCM0024  KB05 MOLM-16 C493(2.10)  LDD3334  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578