Details of the Target

General Information of Target

Target ID LDTP07852
Target Name Storkhead-box protein 1 (STOX1)
Gene Name STOX1
Gene ID 219736
Synonyms
C10orf24; Storkhead-box protein 1; Winged-helix domain-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARPVQLAPGSLALVLCRLEAQKAAGAAEEPGGRAVFRAFRRANARCFWNARLARAASRL
AFQGWLRRGVLLVRAPPACLQVLRDAWRRRALRPPRGFRIRAVGDVFPVQMNPITQSQFV
PLGEVLCCAISDMNTAQIVVTQESLLERLMKHYPGIAIPSEDILYTTLGTLIKERKIYHT
GEGYFIVTPQTYFITNTTTQENKRMLPSDESRLMPASMTYLVSMESCAESAQENAAPISH
CQSCQCFRDMHTQDVQEAPVAAEVTRKSHRGLGESVSWVQNGAVSVSAEHHICESTKPLP
YTRDKEKGKKFGFSLLWRSLSRKEKPKTEHSSFSAQFPPEEWPVRDEDDLDNIPRDVEHE
IIKRINPILTVDNLIKHTVLMQKYEEQKKYNSQGTSTDMLTIGHKYPSKEGVKKRQGLSA
KPQGQGHSRRDRHKARNQGSEFQPGSIRLEKHPKLPATQPIPRIKSPNEMVGQKPLGEIT
TVLGSHLIYKKRISNPFQGLSHRGSTISKGHKIQKTSDLKPSQTGPKEKPFQKPRSLDSS
RIFDGKAKEPYAEQPNDKMEAESIYINDPTVKPINDDFRGHLFSHPQQSMLQNDGKCCPF
MESMLRYEVYGGENEVIPEVLRKSHSHFDKLGETKQTPHSLPSRGASFSDRTPSACRLVD
NTIHQFQNLGLLDYPVGVNPLRQAARQDKDSEELLRKGFVQDAETTSLENEQLSNDDQAL
YQNEVEDDDGACSSLYLEEDDISENDDLRQMLPGHSQYSFTGGSQGNHLGKQKVIERSLT
EYNSTMERVESQVLKRNECYKPTGLHATPGESQEPNLSAESCGLNSGAQFGFNYEEEPSV
AKCVQASAPADERIFDYYSARKASFEAEVIQDTIGDTGKKPASWSQSPQNQEMRKHFPQK
FQLFNTSHMPVLAQDVQYEHSHLEGTENHSMAGDSGIDSPRTQSLGSNNSVILDGLKRRQ
NFLQNVEGTKSSQPLTSNSLLPLTPVINV
Target Bioclass
Other
Subcellular location
Cytoplasm; Nucleus; Nucleus, nucleolus
Function
Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway.; [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.
Uniprot ID
Q6ZVD7
Ensemble ID
ENST00000298596.11
HGNC ID
HGNC:23508

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.E633K .
DU145 SNV: p.D716N .
HCT116 SNV: p.A39D; p.A78T .
HCT15 SNV: p.R266M; p.S331I .
HT SNV: p.K520N .
HUH1 SNV: p.Y184C .
ICC108 SNV: p.Q889E .
JHH4 SNV: p.C241Y .
LS123 SNV: p.C597F .
NCIH358 SNV: p.P407A .
RCC10RGB SNV: p.C598S .
RKO Deletion: p.K900SfsTer38 .
SNGM Deletion: p.G123VfsTer11
SNV: p.N391D		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C843(1.17)  LDD1513  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C843(1.17)  LDD1513  [1]
 LDCM0283  AC23 HEK-293T C843(1.17)  LDD1522  [1]
 LDCM0292  AC31 HEK-293T C843(0.91)  LDD1531  [1]
 LDCM0300  AC39 HEK-293T C843(1.04)  LDD1539  [1]
 LDCM0309  AC47 HEK-293T C843(1.16)  LDD1548  [1]
 LDCM0318  AC55 HEK-293T C843(1.03)  LDD1557  [1]
 LDCM0327  AC63 HEK-293T C843(1.09)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C843(1.16)  LDD1568  [1]
 LDCM0379  CL11 HEK-293T C843(1.21)  LDD1583  [1]
 LDCM0411  CL23 HEK-293T C843(1.10)  LDD1615  [1]
 LDCM0424  CL35 HEK-293T C843(1.23)  LDD1628  [1]
 LDCM0437  CL47 HEK-293T C843(1.31)  LDD1641  [1]
 LDCM0450  CL59 HEK-293T C843(1.40)  LDD1653  [1]
 LDCM0464  CL71 HEK-293T C843(1.36)  LDD1667  [1]
 LDCM0477  CL83 HEK-293T C843(1.07)  LDD1680  [1]
 LDCM0490  CL95 HEK-293T C843(1.14)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402