Details of the Target
General Information of Target
| Target ID | LDTP07832 | |||||
|---|---|---|---|---|---|---|
| Target Name | Bargin (BARGIN) | |||||
| Gene Name | BARGIN | |||||
| Synonyms |
Bargin; Chimeric SH3BP1-PDXP protein |
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| 3D Structure | ||||||
| Sequence |
MDRGLPGPATPAVTPQPPARPQDDEEAAAPHAAAGPDGQLGTVEQRLEPAKRAAHNIHKR
LQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARIL AEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGL GGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLE IQADYHRRSLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALP IEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYL RELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEE QEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGD INFNVSGLFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKE RTESEVPPRPASPKVTRSPPETAAPVEDMARRSTGSLAAAVETASGRQALVVGKPSPYMF ECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLV PHYYVESIADLTEGLED |
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| Target Bioclass |
Other
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| Subcellular location |
Cell membrane
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| Function |
GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and K-48 polyubiquitin chains.
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| Uniprot ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K59(5.62) | LDD0277 | [1] | |
|
BTD Probe Info |
 |
C396(1.44) | LDD2099 | [2] | |
|
W1 Probe Info |
 |
E394(0.83) | LDD0239 | [3] | |
|
IA-alkyne Probe Info |
 |
C213(0.00); C631(0.00); C64(0.00) | LDD0165 | [4] | |
|
IPM Probe Info |
 |
C64(0.00); C110(0.00) | LDD2156 | [5] | |
|
NAIA_5 Probe Info |
 |
C110(0.00); C631(0.00); C64(0.00) | LDD2223 | [6] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0632 | CL-Sc | Hep-G2 | C110(0.85) | LDD2227 | [6] |
| LDCM0506 | Nucleophilic fragment 16a | MDA-MB-231 | C396(1.44) | LDD2099 | [2] |
| LDCM0552 | Nucleophilic fragment 6a | MDA-MB-231 | C396(3.80) | LDD2146 | [2] |
| LDCM0627 | NUDT7-COV-1 | HEK-293T | C110(0.73) | LDD2206 | [7] |
| LDCM0628 | OTUB2-COV-1 | HEK-293T | C110(0.88) | LDD2207 | [7] |
| LDCM0112 | W16 | Hep-G2 | E394(0.83) | LDD0239 | [3] |
References