Details of the Target

General Information of Target

Target ID LDTP07792
Target Name Lysophospholipid acyltransferase 1 (MBOAT1)
Gene Name MBOAT1
Gene ID 154141
Synonyms
OACT1; Lysophospholipid acyltransferase 1; LPLAT 1; 1-acylglycerophosphocholine O-acyltransferase; EC 2.3.1.23; 1-acylglycerophosphoethanolamine O-acyltransferase; EC 2.3.1.n7; 1-acylglycerophosphoserine O-acyltransferase MBOAT1; EC 2.3.1.n6; Lysophosphatidylserine acyltransferase; LPSAT; Lyso-PS acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 1; O-acyltransferase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTS
SDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTI
CHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKP
SFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTGA
VIHKLGITLVSLLLFLTLTKTFPVTCLVDDWFVHKASFPARLCYLYVVMQASKPKYYFAW
TLADAVNNAAGFGFSGVDKNGNFCWDLLSNLNIWKIETATSFKMYLENWNIQTATWLKCV
CYQRVPWYPTVLTFILSALWHGVYPGYYFTFLTGILVTLAARAVRNNYRHYFLSSRALKA
VYDAGTWAVTQLAVSYTVAPFVMLAVEPTISLYKSMYFYLHIISLLIILFLPMKPQAHTQ
RRPQTLNSINKRKTD
Target Bioclass
Enzyme
Family
Membrane-bound acyltransferase family
Subcellular location
Membrane
Function
Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine. Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor. May play a role in neurite outgrowth during neuronal differentiation.
Uniprot ID
Q6ZNC8
Ensemble ID
ENST00000324607.8
HGNC ID
HGNC:21579

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.I463T .
RH41 SNV: p.P440T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C266(1.08)  LDD1513  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C266(1.08)  LDD1513  [1]
 LDCM0283  AC23 HEK-293T C266(0.92)  LDD1522  [1]
 LDCM0292  AC31 HEK-293T C266(1.04)  LDD1531  [1]
 LDCM0300  AC39 HEK-293T C266(0.98)  LDD1539  [1]
 LDCM0309  AC47 HEK-293T C266(0.87)  LDD1548  [1]
 LDCM0318  AC55 HEK-293T C266(0.94)  LDD1557  [1]
 LDCM0327  AC63 HEK-293T C266(0.98)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C266(0.96)  LDD1568  [1]
 LDCM0379  CL11 HEK-293T C266(1.14)  LDD1583  [1]
 LDCM0411  CL23 HEK-293T C266(1.01)  LDD1615  [1]
 LDCM0424  CL35 HEK-293T C266(1.00)  LDD1628  [1]
 LDCM0437  CL47 HEK-293T C266(1.20)  LDD1641  [1]
 LDCM0450  CL59 HEK-293T C266(0.99)  LDD1653  [1]
 LDCM0464  CL71 HEK-293T C266(1.09)  LDD1667  [1]
 LDCM0477  CL83 HEK-293T C266(1.10)  LDD1680  [1]
 LDCM0490  CL95 HEK-293T C266(1.00)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402