Details of the Target

General Information of Target

Target ID LDTP07748
Target Name RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
Gene Name RBMS3
Gene ID 27303
Synonyms
RNA-binding motif, single-stranded-interacting protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKRLDQPQMYPQYTYYYPHYLQTKQSYAPAPHPMAPPSPSTNSSSNNSSNNSSGEQLSK
TNLYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVA
SLKANGVQAQMAKQQEQDPTNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSR
GVGFARMESTEKCEVVIQHFNGKYLKTPPGIPAPSEPLLCKFADGGQKKRQNQSKYTQNG
RPWPREGEAGMALTYDPTAAIQNGFYSSPYSIATNRMIPQTSITPFIAASPVSTYQVQST
SWMPHPPYVMQPTGAVITPTMDHPMSMQPANMMGPLTQQMNHLSLGTTGTIQSQDRIMIL
HQLLCQYMTAAAPMQGTYIPQYTPVPPTAVSIEGVVADTSPQTVAPSSQDTSGQQQQIAV
DTSNEHAPAYSYQQSKP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds poly(A) and poly(U) oligoribonucleotides.
Uniprot ID
Q6XE24
Ensemble ID
ENST00000273139.13
HGNC ID
HGNC:13427

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KATOIII SNV: p.Q352K .
LN229 SNV: p.E136K .
ONS76 SNV: p.A114D .
PF382 SNV: p.A115T .
SKMM2 SNV: p.Q238E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C101(0.81)  LDD3353  [1]
BTD
 Probe Info  		C101(1.19)  LDD2093  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C101(0.88)  LDD2117  [2]
 LDCM0022  KB02 CAL-62 C101(1.48)  LDD2289  [1]
 LDCM0023  KB03 8305C C101(0.92)  LDD2665  [1]
 LDCM0024  KB05 NCI-H2052 C101(0.81)  LDD3353  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C101(1.19)  LDD2093  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C101(0.77)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C101(0.81)  LDD2111  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C101(0.94)  LDD2120  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C101(0.58)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C101(0.99)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C101(1.10)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C101(0.97)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C101(0.98)  LDD2137  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C101(1.15)  LDD2143  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C101(0.86)  LDD2145  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C101(0.49)  LDD2148  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761