Details of the Target

General Information of Target

Target ID LDTP07720
Target Name Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (BAIAP2L2)
Gene Name BAIAP2L2
Gene ID 80115
Synonyms
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; BAI1-associated protein 2-like protein 2; Planar intestinal- and kidney-specific BAR domain protein; Pinkbar
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPEMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHALSEAAEVYFSAIQKIGE
RALQSPTSQILGEILVQMSDTQRHLNSDLEVVVQTFHGGLLQHMEKNTKLDMQFIKDSRQ
HYELEYRHRAANLEKCMSELWRMERKRDKNVREMKESVNRLHAQMQAFVSESQRAAELEE
KRRYRFLAEKHLLLSNTFLQFFGRARGMLQNRVLLWKEQSEASRSPSRAHSPGLLGPALG
PPYPSGRLTPTCLDMPPRPLGEFSSPRSRHGSGSYGTEPDARPASQLEPDRRSLPRTPSA
SSLYSGSAQSSRSNSFGERPGGGGGARRVRALVSHSEGANHTLLRFSAGDVVEVLVPEAQ
NGWLYGKLEGSSASGWFPEAYVKALEEGPVNPMTPVTPMTSMTSMSPMTPMNPGNELPSR
SYPLRGSHSLDDLLDRPGNSIAPSEYWDGQSRSRTPSRVPSRAPSPAPPPLPSSRRSSMG
STAVATDVKKLMSSEQYPPQELFPRGTNPFATVKLRPTITNDRSAPLIR
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide.
Uniprot ID
Q6UXY1
Ensemble ID
ENST00000381669.8
HGNC ID
HGNC:26203

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC Deletion: p.E387del .
MDAMB468 SNV: p.A326G .
MKN45 SNV: p.D280A .
P31FUJ SNV: p.R267S .
RKO Deletion: p.R267AfsTer21 .
RL952 Insertion: p.R267PfsTer166 .
T98G Deletion: p.V396Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C252(4.85)  LDD3389  [1]
BTD
 Probe Info  		C136(1.40)  LDD2089  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C136(0.60)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C136(0.59)  LDD2130  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C136(0.50)  LDD2132  [2]
 LDCM0545  Acetamide MDA-MB-231 C136(0.80)  LDD2138  [2]
 LDCM0498  BS-3668 MDA-MB-231 C136(0.86)  LDD2091  [2]
 LDCM0022  KB02 ICC19 C252(1.30)  LDD2386  [1]
 LDCM0023  KB03 ICC19 C252(1.36)  LDD2803  [1]
 LDCM0024  KB05 OZ C252(4.85)  LDD3389  [1]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C136(1.40)  LDD2089  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761