Details of the Target

General Information of Target

Target ID LDTP07664
Target Name All-trans retinoic acid-induced differentiation factor (ATRAID)
Gene Name ATRAID
Gene ID 51374
Synonyms
APR3; C2orf28; All-trans retinoic acid-induced differentiation factor; Apoptosis-related protein 3; APR-3; p18
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPHDPGSLTTLVPWAAALLLALGVERALALPEICTQCPGSVQNLSKVAFYCKTTRELML
HARCCLNQKGTILGLDLQNCSLEDPGPNFHQAHTTVIIDLQANPLKGDLANTFRGFTQLQ
TLILPQHVNCPGGINAWNTITSYIDNQICQGQKNLCNNTGDPEMCPENGSCVPDGPGLLQ
CVCADGFHGYKCMRQGSFSLLMFFGILGATTLSVSILLWATQRRKAKTS
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Subcellular location
Nucleus envelope
Function
Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol.
TTD ID
T96398
Uniprot ID
Q6UW56
DrugMap ID
TTFLIKM
Ensemble ID
ENST00000380171.9
HGNC ID
HGNC:24090

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C52(2.94)  LDD3346  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C130(1.00)  LDD1508  [4]
 LDCM0270  AC15 HEK-293T C183(0.94)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C130(0.90)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C130(0.93)  LDD1518  [4]
 LDCM0281  AC21 HEK-293T C130(1.21)  LDD1520  [4]
 LDCM0283  AC23 HEK-293T C183(0.89)  LDD1522  [4]
 LDCM0286  AC26 HEK-293T C130(0.84)  LDD1525  [4]
 LDCM0289  AC29 HEK-293T C130(1.04)  LDD1528  [4]
 LDCM0292  AC31 HEK-293T C183(0.82)  LDD1531  [4]
 LDCM0295  AC34 HEK-293T C130(0.91)  LDD1534  [4]
 LDCM0298  AC37 HEK-293T C130(1.00)  LDD1537  [4]
 LDCM0300  AC39 HEK-293T C183(1.12)  LDD1539  [4]
 LDCM0304  AC42 HEK-293T C130(1.01)  LDD1543  [4]
 LDCM0307  AC45 HEK-293T C130(1.07)  LDD1546  [4]
 LDCM0309  AC47 HEK-293T C183(1.16)  LDD1548  [4]
 LDCM0312  AC5 HEK-293T C130(1.08)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C130(0.84)  LDD1552  [4]
 LDCM0316  AC53 HEK-293T C130(1.04)  LDD1555  [4]
 LDCM0318  AC55 HEK-293T C183(1.08)  LDD1557  [4]
 LDCM0321  AC58 HEK-293T C130(0.86)  LDD1560  [4]
 LDCM0325  AC61 HEK-293T C130(1.21)  LDD1564  [4]
 LDCM0327  AC63 HEK-293T C183(1.10)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C183(0.93)  LDD1568  [4]
 LDCM0248  AKOS034007472 HEK-293T C130(1.25)  LDD1511  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C130(1.23)  LDD1571  [4]
 LDCM0370  CL101 HEK-293T C130(0.99)  LDD1574  [4]
 LDCM0374  CL105 HEK-293T C130(1.08)  LDD1578  [4]
 LDCM0378  CL109 HEK-293T C130(1.13)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C183(1.02)  LDD1583  [4]
 LDCM0383  CL113 HEK-293T C130(1.31)  LDD1587  [4]
 LDCM0387  CL117 HEK-293T C130(1.15)  LDD1591  [4]
 LDCM0392  CL121 HEK-293T C130(0.97)  LDD1596  [4]
 LDCM0396  CL125 HEK-293T C130(1.03)  LDD1600  [4]
 LDCM0400  CL13 HEK-293T C130(1.13)  LDD1604  [4]
 LDCM0405  CL18 HEK-293T C130(1.00)  LDD1609  [4]
 LDCM0409  CL21 HEK-293T C130(1.04)  LDD1613  [4]
 LDCM0411  CL23 HEK-293T C183(1.13)  LDD1615  [4]
 LDCM0413  CL25 HEK-293T C130(0.89)  LDD1617  [4]
 LDCM0419  CL30 HEK-293T C130(0.88)  LDD1623  [4]
 LDCM0422  CL33 HEK-293T C130(1.25)  LDD1626  [4]
 LDCM0424  CL35 HEK-293T C183(1.16)  LDD1628  [4]
 LDCM0426  CL37 HEK-293T C130(1.01)  LDD1630  [4]
 LDCM0432  CL42 HEK-293T C130(0.98)  LDD1636  [4]
 LDCM0435  CL45 HEK-293T C130(1.11)  LDD1639  [4]
 LDCM0437  CL47 HEK-293T C183(1.12)  LDD1641  [4]
 LDCM0439  CL49 HEK-293T C130(1.31)  LDD1643  [4]
 LDCM0445  CL54 HEK-293T C130(0.91)  LDD1648  [4]
 LDCM0448  CL57 HEK-293T C130(1.19)  LDD1651  [4]
 LDCM0450  CL59 HEK-293T C183(1.13)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C130(0.95)  LDD1654  [4]
 LDCM0453  CL61 HEK-293T C130(1.16)  LDD1656  [4]
 LDCM0458  CL66 HEK-293T C130(0.90)  LDD1661  [4]
 LDCM0461  CL69 HEK-293T C130(1.20)  LDD1664  [4]
 LDCM0464  CL71 HEK-293T C183(1.35)  LDD1667  [4]
 LDCM0466  CL73 HEK-293T C130(0.96)  LDD1669  [4]
 LDCM0471  CL78 HEK-293T C130(0.90)  LDD1674  [4]
 LDCM0475  CL81 HEK-293T C130(1.14)  LDD1678  [4]
 LDCM0477  CL83 HEK-293T C183(1.03)  LDD1680  [4]
 LDCM0479  CL85 HEK-293T C130(0.88)  LDD1682  [4]
 LDCM0484  CL9 HEK-293T C130(1.31)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C130(0.82)  LDD1688  [4]
 LDCM0488  CL93 HEK-293T C130(1.10)  LDD1691  [4]
 LDCM0490  CL95 HEK-293T C183(1.01)  LDD1693  [4]
 LDCM0492  CL97 HEK-293T C130(0.78)  LDD1695  [4]
 LDCM0022  KB02 786-O C52(2.98)  LDD2247  [1]
 LDCM0023  KB03 786-O C52(4.49)  LDD2664  [1]
 LDCM0024  KB05 NCI-H1666 C52(2.94)  LDD3346  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
55 kDa erythrocyte membrane protein (MPP1) MAGUK family Q00013
Sorting nexin-9 (SNX9) Sorting nexin family Q9Y5X1
Protein kinase C-binding protein NELL1 (NELL1) . Q92832

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402