Details of the Target

General Information of Target

Target ID LDTP07474
Target Name Zinc finger protein 746 (ZNF746)
Gene Name ZNF746
Gene ID 155061
Synonyms
PARIS; Zinc finger protein 746; Parkin-interacting substrate; PARIS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEAVAAPISPWTMAATIQAMERKIESQAARLLSLEGRTGMAEKKLADCEKTAVEFGNQL
EGKWAVLGTLLQEYGLLQRRLENVENLLRNRNFWILRLPPGSKGESPKEWGKLEDWQKEL
YKHVMRGNYETLVSLDYAISKPEVLSQIEQGKEPCNWRRPGPKIPDVPVDPSPGSGPPVP
APDLLMQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVH
SNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVH
PTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSP
AVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRP
FNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDG
SGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRMLHTGERPFPC
TECEKRFTERSKLIDHYRTHTGVRPFTCTVCGKSFIRKDHLRKHQRNHAAGAKTPARGQP
LPTPPAPPDPFKSPASKGPLASTDLVTDWTCGLSVLGPTDGGDM
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Cytoplasm
Function
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Uniprot ID
Q6NUN9
Ensemble ID
ENST00000340622.8
HGNC ID
HGNC:21948

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C476(0.67)  LDD3323  [1]
AHL-Pu-1
 Probe Info  		C425(20.00)  LDD0171  [2]
IA-alkyne
 Probe Info  		C385(6.47)  LDD1705  [3]
Acrolein
 Probe Info  		N.A.  LDD0223  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
IPM
 Probe Info  		N.A.  LDD0147  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C425(20.00)  LDD0171  [2]
 LDCM0214  AC1 HEK-293T C385(1.06)  LDD1507  [7]
 LDCM0276  AC17 HEK-293T C385(1.16)  LDD1515  [7]
 LDCM0285  AC25 HEK-293T C385(1.11)  LDD1524  [7]
 LDCM0294  AC33 HEK-293T C385(1.11)  LDD1533  [7]
 LDCM0303  AC41 HEK-293T C385(1.08)  LDD1542  [7]
 LDCM0311  AC49 HEK-293T C385(1.11)  LDD1550  [7]
 LDCM0320  AC57 HEK-293T C385(1.12)  LDD1559  [7]
 LDCM0356  AKOS034007680 HEK-293T C385(1.01)  LDD1570  [7]
 LDCM0404  CL17 HEK-293T C385(1.21)  LDD1608  [7]
 LDCM0417  CL29 HEK-293T C385(1.08)  LDD1621  [7]
 LDCM0431  CL41 HEK-293T C385(1.14)  LDD1635  [7]
 LDCM0440  CL5 HEK-293T C385(1.12)  LDD1644  [7]
 LDCM0444  CL53 HEK-293T C385(1.10)  LDD1647  [7]
 LDCM0457  CL65 HEK-293T C385(1.16)  LDD1660  [7]
 LDCM0470  CL77 HEK-293T C385(1.14)  LDD1673  [7]
 LDCM0483  CL89 HEK-293T C385(1.01)  LDD1686  [7]
 LDCM0022  KB02 HEK-293T C385(1.00)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C385(1.06)  LDD1497  [7]
 LDCM0024  KB05 SKMEL24 C476(0.67)  LDD3323  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase parkin (PRKN) RBR family, Parkin subfamily O60260

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402