Details of the Target
General Information of Target
| Target ID | LDTP07468 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2) | |||||
| Gene Name | GPAT2 | |||||
| Gene ID | 150763 | |||||
| Synonyms |
Glycerol-3-phosphate acyltransferase 2, mitochondrial; GPAT-2; EC 2.3.1.15; 1-acylglycerol-3-phosphate O-acyltransferase GPAT2; EC 2.3.1.51; xGPAT1 |
|||||
| 3D Structure | ||||||
| Sequence |
MATMLEGRCQTQPRSSPSGREASLWSSGFGMKLEAVTPFLGKYRPFVGRCCQTCTPKSWE
SLFHRSITDLGFCNVILVKEENTRFRGWLVRRLCYFLWSLEQHIPPCQDVPQKIMESTGV QNLLSGRVPGGTGEGQVPDLVKKEVQRILGHIQAPPRPFLVRLFSWALLRFLNCLFLNVQ LHKGQMKMVQKAAQAGLPLVLLSTHKTLLDGILLPFMLLSQGLGVLRVAWDSRACSPALR ALLRKLGGLFLPPEASLSLDSSEGLLARAVVQAVIEQLLVSGQPLLIFLEEPPGALGPRL SALGQAWVGFVVQAVQVGIVPDALLVPVAVTYDLVPDAPCDIDHASAPLGLWTGALAVLR SLWSRWGCSHRICSRVHLAQPFSLQEYIVSARSCWGGRQTLEQLLQPIVLGQCTAVPDTE KEQEWTPITGPLLALKEEDQLLVRRLSCHVLSASVGSSAVMSTAIMATLLLFKHQKLLGE FSWLTEEILLRGFDVGFSGQLRSLLQHSLSLLRAHVALLRIRQGDLLVVPQPGPGLTHLA QLSAELLPVFLSEAVGACAVRGLLAGRVPPQGPWELQGILLLSQNELYRQILLLMHLLPQ DLLLLKPCQSSYCYCQEVLDRLIQCGLLVAEETPGSRPACDTGRQRLSRKLLWKPSGDFT DSDSDDFGEADGRYFRLSQQSHCPDFFLFLCRLLSPLLKAFAQAAAFLRQGQLPDTELGY TEQLFQFLQATAQEEGIFECADPKLAISAVWTFRDLGVLQQTPSPAGPRLHLSPTFASLD NQEKLEQFIRQFICS |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
GPAT/DAPAT family
|
|||||
| Subcellular location |
Mitochondrion outer membrane
|
|||||
| Function |
Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C235(1.29) | LDD2477 | [1] | |
|
AHL-Pu-1 Probe Info |
 |
C413(3.25) | LDD0170 | [2] | |
|
IPM Probe Info |
 |
C9(7.29); C235(0.99) | LDD1701 | [3] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0025 | 4SU-RNA | DM93 | C413(3.25) | LDD0170 | [2] |
| LDCM0026 | 4SU-RNA+native RNA | DM93 | C683(2.08) | LDD0171 | [2] |
| LDCM0213 | Electrophilic fragment 2 | MDA-MB-231 | C9(2.14) | LDD1702 | [3] |
| LDCM0022 | KB02 | G361 | C235(1.29) | LDD2477 | [1] |
| LDCM0023 | KB03 | MDA-MB-231 | C9(7.29); C235(0.99) | LDD1701 | [3] |
| LDCM0024 | KB05 | CHL1 | C235(2.68) | LDD3309 | [1] |
References