Details of the Target

General Information of Target

Target ID LDTP07353
Target Name Protein WWC2 (WWC2)
Gene Name WWC2
Gene ID 80014
Synonyms
BOMB; Protein WWC2; BH-3-only member B; WW domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELP
WGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKMLKDYLSVAQDALRTQKELYHV
KEQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEISTTRLRVKKLKR
ELSQMKQELLYKEQGFETLQQIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQ
DLMQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRS
NLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINEKEELLKELQF
VTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERLRLEERRKELLQKLEETTKLT
TYLHSQLKSLSASTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDV
DYQYKLDFLLQEKSGYIPSGPITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAP
KSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLI
ENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSA
AVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETAQVQIGLRYNAKSSSFMVIIA
QLRNLHAFLIPHTSKVYFRVAVLPSSTDVSCLFRTKVHPPTESILFNDVFRVAISQTALQ
QKTLRVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDS
VFQPNQPLVDSIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLR
EASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPT
LVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIVRSQTFSPGERNQYICRLNRS
DSDSSTLAKKSLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVRTSLDLELDLQASLTRQ
SRLNDELQALRDLRQKLEELKAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGL
NAEKLMRQVSKDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV
Target Bioclass
Other
Family
WWC family
Function
Negative regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway.
Uniprot ID
Q6AWC2
Ensemble ID
ENST00000403733.8
HGNC ID
HGNC:24148

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CORL88 SNV: p.E384Ter .
EFO27 SNV: p.R1082H .
HCT116 Deletion: p.G62DfsTer24; p.M206CfsTer17 .
HCT15 SNV: p.R93W .
HT115 SNV: p.I85V .
JURKAT SNV: p.R1117S .
NCIH1666 SNV: p.P811S .
P31FUJ SNV: p.L552I .
REH SNV: p.A447V .
RKO Deletion: p.E911RfsTer16 .
SW1783 SNV: p.V849L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K226(8.25)  LDD0277  [1]
DBIA
 Probe Info  		C1061(101.94); C1050(48.73)  LDD0209  [2]
CY-1
 Probe Info  		N.A.  LDD0246  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1061(1.02)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C1061(1.11); C1050(0.99)  LDD1508  [5]
 LDCM0237  AC12 HEK-293T C1050(0.96)  LDD1510  [5]
 LDCM0276  AC17 HEK-293T C1061(1.20)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C1061(0.99); C1050(1.00)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C1061(1.16); C1050(1.00)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C1050(1.00)  LDD1519  [5]
 LDCM0285  AC25 HEK-293T C1061(1.13)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C1061(1.19); C1050(1.05)  LDD1525  [5]
 LDCM0288  AC28 HEK-293T C1050(0.98)  LDD1527  [5]
 LDCM0294  AC33 HEK-293T C1061(0.95)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C1061(1.20); C1050(1.09)  LDD1534  [5]
 LDCM0297  AC36 HEK-293T C1050(0.91)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C1050(0.94)  LDD1540  [5]
 LDCM0303  AC41 HEK-293T C1061(1.14)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C1061(1.19); C1050(1.15)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C1050(1.00)  LDD1545  [5]
 LDCM0311  AC49 HEK-293T C1061(1.17)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C1061(1.24); C1050(0.90)  LDD1552  [5]
 LDCM0315  AC52 HEK-293T C1050(1.02)  LDD1554  [5]
 LDCM0320  AC57 HEK-293T C1061(1.09)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C1061(0.90); C1050(0.99)  LDD1560  [5]
 LDCM0324  AC60 HEK-293T C1050(1.04)  LDD1563  [5]
 LDCM0356  AKOS034007680 HEK-293T C1061(1.10)  LDD1570  [5]
 LDCM0367  CL1 HEK-293T C1061(1.12)  LDD1571  [5]
 LDCM0370  CL101 HEK-293T C1061(1.13)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C1050(0.94)  LDD1576  [5]
 LDCM0374  CL105 HEK-293T C1061(1.03)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C1050(0.96)  LDD1580  [5]
 LDCM0378  CL109 HEK-293T C1061(1.03)  LDD1582  [5]
 LDCM0381  CL111 HEK-293T C1050(1.17)  LDD1585  [5]
 LDCM0383  CL113 HEK-293T C1061(1.15)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C1050(0.89)  LDD1589  [5]
 LDCM0387  CL117 HEK-293T C1061(1.26)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C1050(1.04)  LDD1593  [5]
 LDCM0392  CL121 HEK-293T C1061(1.00)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C1050(1.05)  LDD1598  [5]
 LDCM0396  CL125 HEK-293T C1061(1.11)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C1050(1.03)  LDD1602  [5]
 LDCM0400  CL13 HEK-293T C1061(1.32)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C1050(0.89)  LDD1606  [5]
 LDCM0404  CL17 HEK-293T C1061(1.26)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C1061(1.05); C1050(0.99)  LDD1609  [5]
 LDCM0408  CL20 HEK-293T C1050(1.08)  LDD1612  [5]
 LDCM0413  CL25 HEK-293T C1061(0.96)  LDD1617  [5]
 LDCM0415  CL27 HEK-293T C1050(1.06)  LDD1619  [5]
 LDCM0417  CL29 HEK-293T C1061(0.93)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C1050(0.92)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C1061(1.02); C1050(1.10)  LDD1623  [5]
 LDCM0421  CL32 HEK-293T C1050(1.07)  LDD1625  [5]
 LDCM0426  CL37 HEK-293T C1061(1.16)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C1050(0.97)  LDD1632  [5]
 LDCM0431  CL41 HEK-293T C1061(1.04)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C1061(1.02); C1050(1.09)  LDD1636  [5]
 LDCM0434  CL44 HEK-293T C1050(1.09)  LDD1638  [5]
 LDCM0439  CL49 HEK-293T C1061(1.19)  LDD1643  [5]
 LDCM0440  CL5 HEK-293T C1061(1.10)  LDD1644  [5]
 LDCM0444  CL53 HEK-293T C1061(1.27)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C1061(1.25); C1050(0.96)  LDD1648  [5]
 LDCM0447  CL56 HEK-293T C1050(1.08)  LDD1650  [5]
 LDCM0451  CL6 HEK-293T C1061(1.48); C1050(1.03)  LDD1654  [5]
 LDCM0453  CL61 HEK-293T C1061(1.10)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C1050(1.02)  LDD1658  [5]
 LDCM0457  CL65 HEK-293T C1061(1.12)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C1061(1.26); C1050(1.12)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C1050(1.08)  LDD1663  [5]
 LDCM0466  CL73 HEK-293T C1061(0.99)  LDD1669  [5]
 LDCM0470  CL77 HEK-293T C1061(1.07)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C1061(1.02); C1050(1.07)  LDD1674  [5]
 LDCM0473  CL8 HEK-293T C1050(0.86)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C1050(1.12)  LDD1677  [5]
 LDCM0479  CL85 HEK-293T C1061(1.02)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C1050(1.03)  LDD1684  [5]
 LDCM0483  CL89 HEK-293T C1061(1.03)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C1061(1.12); C1050(0.99)  LDD1688  [5]
 LDCM0487  CL92 HEK-293T C1050(0.96)  LDD1690  [5]
 LDCM0492  CL97 HEK-293T C1061(1.17)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C1050(0.94)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C1050(1.13)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C1050(0.98)  LDD1671  [5]
 LDCM0022  KB02 786-O C970(1.25); C856(2.80); C845(2.26)  LDD2247  [6]
 LDCM0023  KB03 Jurkat C1061(101.94); C1050(48.73)  LDD0209  [2]
 LDCM0024  KB05 OAW-28 C970(1.67)  LDD3368  [6]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840