Details of the Target

General Information of Target

Target ID LDTP07324
Target Name Formin-1 (FMN1)
Gene Name FMN1
Gene ID 342184
Synonyms
FMN; LD; Formin-1; Limb deformity protein homolog
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEGTHCTLQLHKPITELCYISFCLPKGEVRGFSYKGTVTLDRSNKGFHNCYQVREESDII
SLSQEPDEHPGDIFFKQTPTKDILTELYKLTTERERLLTNLLSSDHILGITMGNQEGKLQ
ELSVSLAPEDDCFQSAGDWQGELPVGPLNKRSTHGNKKPRRSSGRRESFGALPQKRTKRK
GRGGRESAPLMGKDKICSSHSLPLSRTRPNLWVLEEKGNLLPNGALACSLQRRESCPPDI
PKTPDTDLGFGSFETAFKDTGLGREVLPPDCSSTEAGGDGIRRPPSGLEHQQTGLSESHQ
DPEKHPEAEKDEMEKPAKRTCKQKPVSKVVAKVQDLSSQVQRVVKTHSKGKETIAIRPAA
HAEFVPKADLLTLPGAEAGAHGSRRQGKERQGDRSSQSPAGETASISSVSASAEGAVNKV
PLKVIESEKLDEAPEGKRLGFPVHTSVPHTRPETRNKRRAGLPLGGHKSLFLDLPHKVGP
DSSQPRGDKKKPSPPAPAALGKVFNNSASQSSTHKQTSPVPSPLSPRLPSPQQHHRILRL
PALPGEREAALNDSPCRKSRVFSGCVSADTLEPPSSAKVTETKGASPAFLRAGQPRLVPG
ETLEKSLGPGKTTAEPQHQSPPGISSEGFPWDGFNEQTPKDLPNRDGGAWVLGYRAGPAC
PFLLHEEREKSNRSELYLDLHPDHSLTEQDDRTPGRLQAVWPPPKTKDTEEKVGLKYTEA
EYQAAILHLKREHKEEIENLQAQFELRAFHIRGEHAMITARLEETIENLKHELEHRWRGG
CEERKDVCISTDDDCPPKTFRNVCVQTDRETFLKPCESESKTTRSNQLVPKKLNISSLSQ
LSPPNDHKDIHAALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAG
PPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAPPPPPGLF
FGLGSSSSQCPRKPAIEPSCPMKPLYWTRIQISDRSQNATPTLWDSLEEPDIRDPSEFEY
LFSKDTTQQKKKPLSETYEKKNKVKKIIKLLDGKRSQTVGILISSLHLEMKDIQQAIFNV
DDSVVDLETLAALYENRAQEDELVKIRKYYETSKEEELKLLDKPEQFLHELAQIPNFAER
AQCIIFRSVFSEGITSLHRKVEIITRASKDLLHVKSVKDILALILAFGNYMNGGNRTRGQ
ADGYSLEILPKLKDVKSRDNGINLVDYVVKYYLRYYDQEAGTEKSVFPLPEPQDFFLASQ
VKFEDLIKDLRKLKRQLEASEKQMVVVCKESPKEYLQPFKDKLEEFFQKAKKEHKMEESH
LENAQKSFETTVRYFGMKPKSGEKEITPSYVFMVWYEFCSDFKTIWKRESKNISKERLKM
AQESVSKLTSEKKVETKKINPTASLKERLRQKEASVTTN
Target Bioclass
Other
Family
Formin homology family, Cappuccino subfamily
Subcellular location
Nucleus
Function Plays a role in the formation of adherens junction and the polymerization of linear actin cables.
Uniprot ID
Q68DA7
Ensemble ID
ENST00000320930.7
HGNC ID
HGNC:3768

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.E167Ter .
CASKI Substitution: p.S272A .
CCK81 Deletion: p.A416PfsTer2
SNV: p.V829I		 .
CHL1 Substitution: p.S272A DBIA    Probe Info 
D283MED SNV: p.P209S .
HCC827 Substitution: p.S272A .
HS936T SNV: p.G1221E DBIA    Probe Info 
HT SNV: p.D846G .
Ishikawa (Heraklio) 02 ER Deletion: p.P954HfsTer29 .
JHH4 SNV: p.L1062F .
KYSE510 SNV: p.D335N .
LS513 Substitution: p.S272A .
LU65 SNV: p.K258N .
MCC13 SNV: p.P374S; p.G584R .
MFE280 Substitution: p.S272A .
MFE296 SNV: p.A919T .
NALM6 SNV: p.G859D .
NCIH1155 SNV: p.P609S .
NCIH1792 Substitution: p.S272A .
OCIAML2 Substitution: p.S272A .
PFSK1 Substitution: p.S272A .
REH SNV: p.S512N .
SKMEL28 Substitution: p.S272A DBIA    Probe Info 
SKOV3 SNV: p.T1026A
Substitution: p.S272A		 .
SNU1 Deletion: p.P238QfsTer106
SNV: p.R972Q		 DBIA    Probe Info 
SW756 SNV: p.E735Q .
TCCSUP Substitution: p.S272A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C228(20.00); C816(2.00); C788(5.09)  LDD0170  [1]
DBIA
 Probe Info  		C804(0.99)  LDD0078  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C228(20.00); C816(2.00); C788(5.09)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C816(2.32); C788(5.49); C271(2.06)  LDD0171  [1]
 LDCM0020  ARS-1620 HCC44 C804(0.99)  LDD0078  [2]
 LDCM0022  KB02 A101D C660(4.67); C920(2.25); C804(2.05)  LDD2250  [3]
 LDCM0023  KB03 A101D C660(6.38); C920(3.88); C804(1.86)  LDD2667  [3]
 LDCM0024  KB05 MEL167 C804(1.58)  LDD3316  [3]

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840