Details of the Target

General Information of Target

Target ID LDTP07308
Target Name Nuclear GTPase SLIP-GC (NUGGC)
Gene Name NUGGC
Gene ID 389643
Synonyms
C8orf80; Nuclear GTPase SLIP-GC; EC 3.6.1.-; Speckled-like pattern in the germinal center
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETKDVFGQEPHPVEDDLYKERTRKRRKSDRDQRFRAFPSMEQSALKEYEKLESRTRRV
LSNTYQKLIQSVFLDDSIPNGVKYLINRLLALIEKPTVDPIYIALFGSTGAGKSSLINAI
IQQAMFLPVSGESICTSCIVQVSSGCCVQYEAKIHLLSDQEWREELKNLTKLLHRTEELS
REEADAWNRDEAVEEATWKLQMIYGNGAESKNYEELLRAKPKRKIPTSRVITLKAEEAEE
LSIKLDPYIRTQRRDWDGEAAEMRIWPLIKHVEVTLPKSDLIPEGVVLVDIPGTGDFNSK
RDEMWKKTIDKCSVIWVISDIERVSGGQAHEDLLNESIKACQRGFCRDVALVVTKMDKLH
LPEYLRERKAGNQAIQSQREAVLERNEMIKLQRTRILKEKLKRKLPADFKVLEASDLVYT
VSAQEYWQQALLTEEETEIPKLREYIRKSLLDKKKRTVTKYVTEAFGLLLLTDSFNSTQN
LPNEHLHMSVLRRFAEEKVELLEKAIAQCFACMEQPLQEGVRTARTSYRCILRACLVRSK
GNQGFHQTLKAVCLKNGIYASRTLARIDLNEALTQPVYDQIDPVFGSIFRTGKPTGSALM
PHIDAFKQSLQEKMTEIGIRSGWKYDSCKKNFLIQEISAILGGLEDHILRRKRRIYESLT
ASVQSDLKLCYEEAAQITGKKACERMKDAIRRGVDRQVAEGMFERAQERMQHQFQQLKTG
IVEKVKGSITTMLALASSQGDGLYKELADVGSEYKEMEKLHRSLREVAENARLRKGMQEF
LLRASPSKAGPPGTSL
Target Bioclass
Enzyme
Subcellular location
Nucleus speckle
Function
Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells which may enhance genome stability.
Uniprot ID
Q68CJ6
Ensemble ID
ENST00000413272.7
HGNC ID
HGNC:33550

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		1.22  LDD2183  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos 0.49  LDD2187  [1]
 LDCM0573  Fragment11 Ramos C628(8.54); 0.15  LDD2190  [1]
 LDCM0574  Fragment12 Ramos 1.29  LDD2191  [1]
 LDCM0575  Fragment13 Ramos 1.14  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C628(1.45); 0.93  LDD2193  [1]
 LDCM0580  Fragment21 Ramos 0.86  LDD2195  [1]
 LDCM0578  Fragment27 Ramos 1.16  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C628(0.36)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos 0.39  LDD2199  [1]
 LDCM0589  Fragment31 Ramos 0.90  LDD2200  [1]
 LDCM0468  Fragment33 Ramos 0.83  LDD2202  [1]
 LDCM0596  Fragment38 Ramos 0.37  LDD2203  [1]
 LDCM0610  Fragment52 Ramos 0.62  LDD2204  [1]
 LDCM0614  Fragment56 Ramos 0.89  LDD2205  [1]
 LDCM0569  Fragment7 Ramos 0.94  LDD2186  [1]
 LDCM0023  KB03 Ramos 1.22  LDD2183  [1]
 LDCM0024  KB05 Ramos C628(0.20); 0.73  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578