Details of the Target

General Information of Target

Target ID LDTP07168
Target Name U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C)
Gene Name UTP14C
Gene ID 9724
Synonyms
KIAA0266; U3 small nucleolar RNA-associated protein 14 homolog C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNVNQVAENLALSHQEELVDLPKNYPLSENEDEGDSDGERKHQKLLEAIISLDGKNRRKL
AERSEASLKVSEFSVSSEGSGEKLGLADLLEPVKTSSSLATVKKQLNRVKSKKVVELPLN
KEKIEQIHREVAFSKTSQVLSKWDPIILKNQQAEQLVFPLGKEQPAIAPIEHALSGWKAR
TPLEQEIFNLLHKNKQPVTDPLLTPMEKASLQAMSLEEAKMHRAELQRARALQSYYEAKA
RKEKKIKSKKYHKVVKKGKAKKALKEFEQLQKVNPTVALEEMEKIENARMMERMSLKHQN
SGKWAKSKAIMAKYDLEARQAMQEQLAKNKELTQKLQVASESEEEEGGTEVEELLVPHVA
NEVQMNVDGPNPWMFRSCTSDTKEAATQEDPEQVPELAAHEVSASEAEERPVAEEEILLR
EFEERQSLRKRSELNQDAEPASSQETKDSSSQEVLSELRALSQKLKEKHQSRKQKASSEG
TVPQVQREEPAPEEAEPLLLQRSERVQTLEELEELGKEDCFQNKELPRPVLEGQQSERTP
NNRPDAPKEKKEKEQLINLQNFLTTQSPSVRSLAVPTIIEELEDEEERDQRQMIKEAFAG
DDVIRDFLKEKREAVEASKPKDVDLTLPGWGEWGGVGLKPSAKKRRQFLIKAPEGPPRKD
KNLPNVIISEKRNIHAAAHQVQVLPYPFTHHRQFERTIQTPIGSTWNTQRAFQKLTTPKV
VTKPGHIIKPIKAEDVGYQSSSRSDLPVIQRNPKRITTRHNKEEKL
Target Bioclass
Other
Family
UTP14 family
Subcellular location
Nucleus, nucleolus
Function Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis.
Uniprot ID
Q5TAP6
Ensemble ID
ENST00000521776.2
HGNC ID
HGNC:20321

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y236(35.36)  LDD3495  [1]
AHL-Pu-1
 Probe Info  		C378(2.12)  LDD0169  [2]
DBIA
 Probe Info  		C520(1.04)  LDD1492  [3]
m-APA
 Probe Info  		N.A.  LDD2232  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
ENE
 Probe Info  		N.A.  LDD0006  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
W1
 Probe Info  		E184(0.00); N189(0.00); H192(0.00)  LDD0236  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C378(2.12)  LDD0169  [2]
 LDCM0625  F8 Ramos C378(1.31)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C378(1.14)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C378(20.00)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C378(0.46)  LDD2191  [9]
 LDCM0576  Fragment14 Ramos C378(0.32)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C378(0.53)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C378(0.93)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C378(0.96)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C378(1.03)  LDD2197  [9]
 LDCM0589  Fragment31 Ramos C378(0.50)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C378(0.99)  LDD2201  [9]
 LDCM0566  Fragment4 Ramos C378(1.04)  LDD2184  [9]
 LDCM0614  Fragment56 Ramos C378(0.96)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C378(0.99)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C378(0.63)  LDD2188  [9]
 LDCM0022  KB02 HEK-293T C520(1.04)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C520(1.01)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C520(0.96)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) Class-II pyridoxal-phosphate-dependent aminotransferase family P13196
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6A (GOLGA6A) GOLGA6 family Q9NYA3
Protein Hook homolog 1 (HOOK1) Hook family Q9UJC3
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Colorectal mutant cancer protein (MCC) MCC family P23508
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Alpha-taxilin (TXLNA) Taxilin family P40222
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578