Details of the Target

General Information of Target

Target ID LDTP07157
Target Name E3 ubiquitin-protein ligase RNF187 (RNF187)
Gene Name RNF187
Gene ID 149603
Synonyms
E3 ubiquitin-protein ligase RNF187; EC 2.3.2.27; RING domain AP1 coactivator 1; RACO-1; RING finger protein 187; RING-type E3 ubiquitin transferase RNF187
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALPAGPAEAACALCQRAPREPVRADCGHRFCRACVVRFWAEEDGPFPCPECADDCWQRA
VEPGRPPLSRRLLALEEAAAAPARDGPASEAALQLLCRADAGPLCAACRMAAGPEPPEWE
PRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRA
FFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.
Uniprot ID
Q5TA31
Ensemble ID
ENST00000305943.9
HGNC ID
HGNC:27146

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
DBIA
 Probe Info  		C105(0.95); C108(0.95)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C97(1.01)  LDD1507  [8]
 LDCM0237  AC12 HEK-293T C97(1.01)  LDD1510  [8]
 LDCM0276  AC17 HEK-293T C97(0.76)  LDD1515  [8]
 LDCM0280  AC20 HEK-293T C97(1.04)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C97(0.90)  LDD1520  [8]
 LDCM0285  AC25 HEK-293T C97(0.96)  LDD1524  [8]
 LDCM0288  AC28 HEK-293T C97(1.17)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C97(1.18)  LDD1528  [8]
 LDCM0294  AC33 HEK-293T C97(0.84)  LDD1533  [8]
 LDCM0297  AC36 HEK-293T C97(1.02)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C97(0.88)  LDD1537  [8]
 LDCM0301  AC4 HEK-293T C97(0.95)  LDD1540  [8]
 LDCM0303  AC41 HEK-293T C97(0.71)  LDD1542  [8]
 LDCM0306  AC44 HEK-293T C97(0.94)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C97(0.94)  LDD1546  [8]
 LDCM0311  AC49 HEK-293T C97(0.86)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C97(1.34)  LDD1551  [8]
 LDCM0315  AC52 HEK-293T C97(0.98)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C97(0.99)  LDD1555  [8]
 LDCM0320  AC57 HEK-293T C97(1.06)  LDD1559  [8]
 LDCM0324  AC60 HEK-293T C97(1.11)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C97(1.12)  LDD1564  [8]
 LDCM0248  AKOS034007472 HEK-293T C97(1.07)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C97(0.78)  LDD1570  [8]
 LDCM0020  ARS-1620 HCC44 C105(0.95); C108(0.95)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0404  CL17 HEK-293T C97(0.78)  LDD1608  [8]
 LDCM0408  CL20 HEK-293T C97(0.80)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C97(1.02)  LDD1613  [8]
 LDCM0417  CL29 HEK-293T C97(0.90)  LDD1621  [8]
 LDCM0421  CL32 HEK-293T C97(0.98)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C97(0.65)  LDD1626  [8]
 LDCM0431  CL41 HEK-293T C97(0.99)  LDD1635  [8]
 LDCM0434  CL44 HEK-293T C97(1.13)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C97(0.70)  LDD1639  [8]
 LDCM0440  CL5 HEK-293T C97(0.93)  LDD1644  [8]
 LDCM0444  CL53 HEK-293T C97(1.08)  LDD1647  [8]
 LDCM0447  CL56 HEK-293T C97(1.04)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C97(0.91)  LDD1651  [8]
 LDCM0457  CL65 HEK-293T C97(0.85)  LDD1660  [8]
 LDCM0460  CL68 HEK-293T C97(1.20)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C97(0.89)  LDD1664  [8]
 LDCM0470  CL77 HEK-293T C97(0.79)  LDD1673  [8]
 LDCM0473  CL8 HEK-293T C97(0.73)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C97(0.97)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C97(0.68)  LDD1678  [8]
 LDCM0483  CL89 HEK-293T C97(1.00)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C97(1.26)  LDD1687  [8]
 LDCM0487  CL92 HEK-293T C97(1.02)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C97(1.12)  LDD1691  [8]
 LDCM0022  KB02 HCT 116 C105(3.34); C108(3.34)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C105(2.38); C108(2.38)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C105(1.53); C108(1.53)  LDD0082  [2]
 LDCM0021  THZ1 HCT 116 C105(1.19); C108(1.19)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402