Details of the Target

General Information of Target

Target ID LDTP07100
Target Name Undifferentiated embryonic cell transcription factor 1 (UTF1)
Gene Name UTF1
Gene ID 8433
Synonyms
Undifferentiated embryonic cell transcription factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLRPRRPPPLAPPAPPSPASPDPEPRTPGDAPGTPPRRPASPSALGELGLPVSPGSAQR
TPWSARETELLLGTLLQPAVWRALLLDRRQALPTYRRVSAALAQQQVRRTPAQCRRRYKF
LKDKFREAHGQPPGPFDEQIRKLMGLLGDNGRKRPRRRSPGSGRPQRARRPVPNAHAPAP
SEPDATPLPTARDRDADPTWTLRFSPSPPKSADASPAPGSPPAPAPTALATCIPEDRAPV
RGPGSPPPPPAREDPDSPPGRPEDCAPPPAAPPSLNTALLQTLGHLGDIANILGPLRDQL
LTLNQHVEQLRGAFDQTVSLAVGFILGSAAAERGVLRDPCQ
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Acts as a transcriptional coactivator of ATF2.
Uniprot ID
Q5T230
Ensemble ID
ENST00000304477.3
HGNC ID
HGNC:12634

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C114(1.25)  LDD1512  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C114(1.25)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C114(1.13)  LDD1521  [1]
 LDCM0291  AC30 HEK-293T C114(1.13)  LDD1530  [1]
 LDCM0299  AC38 HEK-293T C114(1.19)  LDD1538  [1]
 LDCM0308  AC46 HEK-293T C114(0.95)  LDD1547  [1]
 LDCM0317  AC54 HEK-293T C114(1.14)  LDD1556  [1]
 LDCM0323  AC6 HEK-293T C114(0.91)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C114(1.06)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C114(1.22)  LDD1572  [1]
 LDCM0410  CL22 HEK-293T C114(1.18)  LDD1614  [1]
 LDCM0423  CL34 HEK-293T C114(1.31)  LDD1627  [1]
 LDCM0436  CL46 HEK-293T C114(1.15)  LDD1640  [1]
 LDCM0449  CL58 HEK-293T C114(1.11)  LDD1652  [1]
 LDCM0463  CL70 HEK-293T C114(1.18)  LDD1666  [1]
 LDCM0476  CL82 HEK-293T C114(1.27)  LDD1679  [1]
 LDCM0489  CL94 HEK-293T C114(0.94)  LDD1692  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.