Details of the Target

General Information of Target

Target ID LDTP07081
Target Name Centrosomal protein of 85 kDa-like (CEP85L)
Gene Name CEP85L
Gene ID 387119
Synonyms
C6orf204; Centrosomal protein of 85 kDa-like; Serologically defined breast cancer antigen NY-BR-15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNHIRRHSIA
SDSGDTGIGTSCSDSVEDHSTSSGTLSFKPSQSLITLPTAHVMPSNSSASISKLRESLTP
DGSKWSTSLMQTLGNHSRGEQDSSLDMKDFRPLRKWSSLSKLTAPDNCGQGGTVCREESR
NGLEKIGKAKALTSQLRTIGPSCLHDSMEMLRLEDKEINKKRSSTLDCKYKFESCSKEDF
RASSSTLRRQPVDMTYSALPESKPIMTSSEAFEPPKYLMLGQQAVGGVPIQPSVRTQMWL
TEQLRTNPLEGRNTEDSYSLAPWQQQQIEDFRQGSETPMQVLTGSSRQSYSPGYQDFSKW
ESMLKIKEGLLRQKEIVIDRQKQQITHLHERIRDNELRAQHAMLGHYVNCEDSYVASLQP
QYENTSLQTPFSEESVSHSQQGEFEQKLASTEKEVLQLNEFLKQRLSLFSEEKKKLEEKL
KTRDRYISSLKKKCQKESEQNKEKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKN
LQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTVQSLQQKVERCLEDGIRLPML
DAKQLQNENDNLRQQNETASKIIDSQQDEIDRMILEIQSMQGKLSKEKLTTQKMMEELEK
KERNVQRLTKALLENQRQTDETCSLLDQGQEPDQSRQQTVLSKRPLFDLTVIDQLFKEMS
CCLFDLKALCSILNQRAQGKEPNLSLLLGIRSMNCSAEETENDHSTETLTKKLSDVCQLR
RDIDELRTTISDRYAQDMGDNCITQ
Target Bioclass
Other
Family
CEP85 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function Plays an essential role in neuronal cell migration.
Uniprot ID
Q5SZL2
Ensemble ID
ENST00000360290.7
HGNC ID
HGNC:21638

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 SNV: p.W125G .
HCC1187 SNV: p.S30P .
HCC1395 SNV: p.S450F .
HT Deletion: p.K551NfsTer16 .
HT115 SNV: p.P23S .
JVM3 SNV: p.P322S .
MCC13 SNV: p.E549D .
MCC26 SNV: p.L97V .
MEWO SNV: p.E478K; p.K571E .
NCIH358 SNV: p.G311V .
SBC5 SNV: p.D215E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K216(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C777(0.92)  LDD1508  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C777(0.92)  LDD1508  [2]
 LDCM0277  AC18 HEK-293T C777(0.91)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C777(0.92)  LDD1518  [2]
 LDCM0286  AC26 HEK-293T C777(1.09)  LDD1525  [2]
 LDCM0295  AC34 HEK-293T C777(0.97)  LDD1534  [2]
 LDCM0304  AC42 HEK-293T C777(0.97)  LDD1543  [2]
 LDCM0313  AC50 HEK-293T C777(0.90)  LDD1552  [2]
 LDCM0321  AC58 HEK-293T C777(1.07)  LDD1560  [2]
 LDCM0369  CL100 HEK-293T C568(1.14)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C568(1.07)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C568(0.97)  LDD1581  [2]
 LDCM0382  CL112 HEK-293T C568(1.07)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C568(1.08)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C568(1.08)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C568(0.99)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C568(1.06)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C568(1.10)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C777(0.99)  LDD1609  [2]
 LDCM0416  CL28 HEK-293T C568(1.07)  LDD1620  [2]
 LDCM0419  CL30 HEK-293T C777(0.95)  LDD1623  [2]
 LDCM0429  CL4 HEK-293T C568(1.11)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C568(1.04)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C777(0.78)  LDD1636  [2]
 LDCM0443  CL52 HEK-293T C568(1.21)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C777(0.86)  LDD1648  [2]
 LDCM0451  CL6 HEK-293T C777(0.93)  LDD1654  [2]
 LDCM0456  CL64 HEK-293T C568(1.09)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C777(0.94)  LDD1661  [2]
 LDCM0469  CL76 HEK-293T C568(1.16)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C777(1.00)  LDD1674  [2]
 LDCM0482  CL88 HEK-293T C568(1.08)  LDD1685  [2]
 LDCM0485  CL90 HEK-293T C777(1.01)  LDD1688  [2]
 LDCM0022  KB02 T cell-activated C228(9.63)  LDD1704  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome non-ATPase regulatory subunit 9 (PSMD9) Proteasome subunit p27 family O00233
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.