Details of the Target

General Information of Target

Target ID	LDTP06936
Target Name	Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADL2)
Gene Name	NAALADL2
Gene ID	254827
Synonyms	Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; NAALADase L2
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESG FDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRC NFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCF HPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQI ALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQV QTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSK VKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLE GPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQN NLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFL VKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYF KAGLDVFKSVLDGKN
Target Bioclass	Enzyme
Family	Peptidase M28 family, M28B subfamily
Subcellular location	Membrane
Function	May be catalytically inactive.
Uniprot ID	Q58DX5
Ensemble ID	ENST00000454872.6
HGNC ID	HGNC:23219

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
A375	SNV: p.D696N	.
HDQP1	SNV: p.G484E	.
IPC298	SNV: p.Q21Ter; p.P340S	.
JHH7	SNV: p.S157T	.
MDAMB453	SNV: p.S341I	.
MFE319	SNV: p.M715T	.
NCIH2286	SNV: p.K425E	.
NCIH661	SNV: p.G727D	.
ONS76	SNV: p.D222N	.
OVK18	SNV: p.D278V	.
PF382	SNV: p.P487A	.
RPMI8226	SNV: p.S457N	.
SKOV3	Insertion: p.I128NfsTer34	.
SUDHL6	SNV: p.Q572E	.
TOV21G	SNV: p.M620I	.
WM1552C	SNV: p.R252Ter	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
CY4 Probe Info			D193(0.00); M194(0.00)	LDD0247	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 3 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3)	Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	Q99726
Integral membrane protein 2B (ITM2B)	ITM2 family	Q9Y287
Lysosomal-associated transmembrane protein 4B (LAPTM4B)	LAPTM4/LAPTM5 transporter family	Q86VI4

GPCR

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Probable G-protein coupled receptor 25 (GPR25)				G-protein coupled receptor 1 family	O00155
Metabotropic glutamate receptor 2 (GRM2)				G-protein coupled receptor 3 family	Q14416

References

1	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.