Details of the Target
General Information of Target
| Target ID | LDTP06920 | |||||
|---|---|---|---|---|---|---|
| Target Name | Retroviral-like aspartic protease 1 (ASPRV1) | |||||
| Gene Name | ASPRV1 | |||||
| Gene ID | 151516 | |||||
| Synonyms |
SASP; Retroviral-like aspartic protease 1; EC 3.4.23.-; Skin-specific retroviral-like aspartic protease; SASPase; Skin aspartic protease; TPA-inducible aspartic proteinase-like protein; TAPS |
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| 3D Structure | ||||||
| Sequence |
MGSPGASLGIKKALQSEQATALPASAPAVSQPTAPAPSCLPKAGQVIPTLLREAPFSSVI
APTLLCGFLFLAWVAAEVPEESSRMAGSGARSEEGRRQHAFVPEPFDGANVVPNLWLHSF EVINDLNHWDHITKLRFLKESLRGEALGVYNRLSPQDQGDYGTVKEALLKAFGVPGAAPS HLPKEIVFANSMGKGYYLKGKIGKVPVRFLVDSGAQVSVVHPNLWEEVTDGDLDTLQPFE NVVKVANGAEMKILGVWDTAVSLGKLKLKAQFLVANASAEEAIIGTDVLQDHNAILDFEH RTCTLKGKKFRLLPVGGSLEDEFDLELIEEDPSSEEGRQELSH |
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| Target Bioclass |
Enzyme
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| Subcellular location |
Membrane
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| Function | Protease responsible for filaggrin processing, essential for the maintenance of a proper epidermis organization. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
TPP-AC Probe Info |
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N.A. | LDD0427 | [1] | |