Details of the Target

General Information of Target

Target ID LDTP06876
Target Name Extracellular tyrosine-protein kinase PKDCC (PKDCC)
Gene Name PKDCC
Gene ID 91461
Synonyms
SGK493; VLK; Extracellular tyrosine-protein kinase PKDCC; EC 2.7.10.2; Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; Sugen kinase 493; Vertebrate lonesome kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPEPSPAPGPGRRGGRGELARQI
RARYEEVQRYSRGGPGPGAGRPERRRLMDLAPGGPGLPRPRPPWARPLSDGAPGWPPAPG
PGSPGPGPRLGCAALRNVSGAQYMGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVR
EFGVRRGCYRLAAHKLLKEMVLLERLRHPNVLQLYGYCYQDSEDIPDTLTTITELGAPVE
MIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTLLDFRPRQFVLVDGELKVTDLDDAR
VEETPCAGSTDCILEFPARNFTLPCSAQGWCEGMNEKRNLYNAYRFFFTYLLPHSAPPSL
RPLLDSIVNATGELAWGVDETLAQLEKVLHLYRSGQYLQNSTASSSTEYQCIPDSTIPQE
DYRCWPSYHHGSCLLSVFNLAEAVDVCESHAQCRAFVVTNQTTWTGRQLVFFKTGWSQVV
PDPNKTTYVKASG
Target Bioclass
Enzyme
Family
Protein kinase superfamily
Subcellular location
Secreted
Function
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane.
Uniprot ID
Q504Y2
Ensemble ID
ENST00000294964.6
HGNC ID
HGNC:25123

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C132(1.41)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C132(1.41)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C132(0.89)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C132(1.29)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C132(1.20)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C132(1.02)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C132(1.10)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C132(0.97)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C132(1.40)  LDD1570  [1]
 LDCM0369  CL100 HEK-293T C132(1.26)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C132(0.96)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C132(1.16)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C132(1.06)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C132(0.92)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C132(1.04)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C132(1.37)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C132(0.93)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C132(1.00)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C132(1.20)  LDD1608  [1]
 LDCM0416  CL28 HEK-293T C132(0.95)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C132(1.19)  LDD1621  [1]
 LDCM0429  CL4 HEK-293T C132(1.55)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C132(1.08)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C132(1.20)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C132(1.20)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C132(1.11)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C132(1.35)  LDD1647  [1]
 LDCM0456  CL64 HEK-293T C132(1.16)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C132(1.14)  LDD1660  [1]
 LDCM0469  CL76 HEK-293T C132(0.98)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C132(1.55)  LDD1673  [1]
 LDCM0482  CL88 HEK-293T C132(1.19)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C132(1.11)  LDD1686  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402