Details of the Target

General Information of Target

Target ID LDTP06824
Target Name CMRF35-like molecule 2 (CD300E)
Gene Name CD300E
Gene ID 342510
Synonyms
CD300LE; CLM2; CMRF35A5; IREM2; CMRF35-like molecule 2; CLM-2; CD300 antigen-like family member E; CMRF35-A5; Immune receptor expressed on myeloid cells 2; IREM-2; Polymeric immunoglobulin receptor 2; PIgR-2; PIgR2; Poly-Ig receptor 2; CD antigen CD300e
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLLPALLLLCLSGCLSLKGPGSVTGTAGDSLTVWCQYESMYKGYNKYWCRGQYDTSCES
IVETKGEEKVERNGRVSIRDHPEALAFTVTMQNLNEDDAGSYWCKIQTVWVLDSWSRDPS
DLVRVYVSPAITTPRRTTHPATPPIFLVVNPGRNLSTGEVLTQNSGFRLSSPHFLLVVLL
KLPLLLSMLGAVFWVNRPQWAPPGR
Target Bioclass
Immunoglobulin
Family
CD300 family
Subcellular location
Cell membrane
Function Probably acts as an activating receptor.
Uniprot ID
Q496F6
Ensemble ID
ENST00000392619.2
HGNC ID
HGNC:28874

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C15(1.02)  LDD2090  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C15(1.02)  LDD2090  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C15(0.40)  LDD2114  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C15(1.89)  LDD2145  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761