Details of the Target

General Information of Target

Target ID LDTP06805
Target Name Transmembrane protein 176B (TMEM176B)
Gene Name TMEM176B
Gene ID 28959
Synonyms
LR8; Transmembrane protein 176B; Protein LR8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTQNTVIVNGVAMASRPSQPTHVNVHIHQESALTQLLKAGGSLKKFLFHPGDTVPSTARI
GYEQLALGVTQILLGVVSCVLGVCLSLGPWTVLSASGCAFWAGSVVIAAGAGAIVHEKHP
GKLAGYISSLLTLAGFATAMAAVVLCVNSFIWQTEPFLYIDTVCDRSDPVFPTTGYRWMR
RSQENQWQKEECRAYMQMLRKLFTAIRALFLAVCVLKVIVSLVSLGVGLRNLCGQSSQPL
NEEGSEKRLLGENSVPPSPSREQTSTAIVL
Target Bioclass
Transporter and channel
Family
TMEM176 family
Subcellular location
Nucleus membrane
Function May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells.
Uniprot ID
Q3YBM2
Ensemble ID
ENST00000326442.10
HGNC ID
HGNC:29596

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.V80A .
NCIH23 SNV: p.R180L .
PATU8988T SNV: p.E252K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C214(1.17)  LDD2113  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C214(0.84)  LDD2117  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C214(0.38)  LDD2132  [1]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C214(0.80)  LDD2131  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C214(1.17)  LDD2113  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C214(0.71)  LDD2115  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C214(1.40)  LDD2116  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C214(1.01)  LDD2120  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C214(1.46)  LDD2122  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C214(0.53)  LDD2140  [1]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C214(1.02)  LDD2149  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761