Details of the Target
General Information of Target
| Target ID | LDTP06733 | |||||
|---|---|---|---|---|---|---|
| Target Name | Chromosome-associated kinesin KIF4B (KIF4B) | |||||
| Gene Name | KIF4B | |||||
| Gene ID | 285643 | |||||
| Synonyms |
Chromosome-associated kinesin KIF4B; Chromokinesin-B |
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| 3D Structure | ||||||
| Sequence |
MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGETQVVVGTDKSFTYDFVFDPCTE
QEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQ LLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKT VLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLHLVD LAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDS LGGNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQ LQVLLLQAHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERI ILTEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDET VACTAAAIDTAVEEEAQVETSPETSRSSDAFTTQHALHQAQMSKEVVELNNALALKEALV RKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNVNQAKLSEHRHK LLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIWMMKNQRVQLMRQMKEDAEK FRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSSVLRRKTEEAAAANKRLKDALQK QREVTDKRKETQSHGKEGIAARVRNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVVQ LKEKKESRENPPPKLRKCTFSLSEVHGQVLESEDCITKQIESLETEMELRSAQIADLQQK LLDAESEDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTKLENSLRQSKASCADMQK MLFEEQNHFSEIETELQAELVRMEQQHQEKVLYLVSQLQESQMAEKQLEKSASEKEQQLV STLQCQDEELEKMREVCEQNQQLLQENEIIKQKLILLQVASRQKHLPNDTLLSPDSSFEY IPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDGDSDEGDDEEWKPTKLVKV SRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCSCDPTKCRNRQQGKDSLGTVEQTQDSEG SFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDMEQVLSKKTAPAPSPFDLPESKHGAT EYQQNKPPGKKKKRALASNTSFFSGCSPIEEEAH |
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| Target Bioclass |
Enzyme
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| Family |
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Chromokinesin subfamily
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| Subcellular location |
Nucleus matrix
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| Function |
Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis. Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C190(3.96) | LDD3320 | [1] | |
|
AHL-Pu-1 Probe Info |
 |
C1226(4.39); C1161(2.08) | LDD0168 | [2] | |
|
HHS-475 Probe Info |
 |
Y80(0.60) | LDD0264 | [3] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0165 | [4] | |
|
NAIA_4 Probe Info |
 |
C312(0.00); C1161(0.00) | LDD2226 | [5] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2225 | [5] | |
|
IPM Probe Info |
 |
N.A. | LDD0005 | [6] | |
|
Acrolein Probe Info |
 |
C1226(0.00); C190(0.00); H763(0.00) | LDD0217 | [7] | |
|
Methacrolein Probe Info |
 |
N.A. | LDD0218 | [7] | |
|
HHS-465 Probe Info |
 |
N.A. | LDD2240 | [8] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0025 | 4SU-RNA | HEK-293T | C1226(4.39); C1161(2.08) | LDD0168 | [2] |
| LDCM0026 | 4SU-RNA+native RNA | HEK-293T | C1226(4.42); C1161(2.28) | LDD0169 | [2] |
| LDCM0116 | HHS-0101 | DM93 | Y80(0.60) | LDD0264 | [3] |
| LDCM0117 | HHS-0201 | DM93 | Y80(0.82) | LDD0265 | [3] |
| LDCM0118 | HHS-0301 | DM93 | Y80(4.81) | LDD0266 | [3] |
| LDCM0120 | HHS-0701 | DM93 | Y80(3.33) | LDD0268 | [3] |
| LDCM0022 | KB02 | 697 | C1161(1.53) | LDD2245 | [1] |
| LDCM0023 | KB03 | 697 | C1161(1.72) | LDD2662 | [1] |
| LDCM0024 | KB05 | RVH421 | C190(3.96) | LDD3320 | [1] |
| LDCM0109 | NEM | HeLa | N.A. | LDD0225 | [7] |
References