Details of the Target
General Information of Target
| Target ID | LDTP06728 | |||||
|---|---|---|---|---|---|---|
| Target Name | Hexokinase HKDC1 (HKDC1) |
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| Gene Name | HKDC1 | |||||
| Gene ID | 80201 | |||||
| Synonyms |
Hexokinase HKDC1; EC 2.7.1.1; Hexokinase domain-containing protein 1 |
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| 3D Structure | ||||||
| Sequence |
MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA
VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI WTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA ALITAVAKRLQQAQKEN |
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| Target Bioclass |
Enzyme
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| Family |
Hexokinase family
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| Subcellular location |
Cytoplasm
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| Function |
Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| AN3CA | SNV: p.C703R | DBIA Probe Info | |||
| HT115 | SNV: p.L349R; p.L385F | DBIA Probe Info | |||
| Ishikawa (Heraklio) 02 ER | SNV: p.D886G | DBIA Probe Info | |||
| JURKAT | SNV: p.C375Y; p.A795V; p.H852R | . | |||
| JVM3 | SNV: p.G750E | . | |||
| MDST8 | SNV: p.P562L | DBIA Probe Info | |||
| MELHO | SNV: p.M412R | DBIA Probe Info | |||
| MELJUSO | SNV: p.A340P | . | |||
| MFE319 | Deletion: p.R844GfsTer7 | DBIA Probe Info | |||
| NCIH716 | Insertion: p.A829GfsTer46 SNV: p.A340P |
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| RCC10RGB | SNV: p.K527E | DBIA Probe Info | |||
| RKO | SNV: p.L152P | DBIA Probe Info | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IPM Probe Info |
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C517(0.00); C627(0.00); C438(0.00); C158(0.00) | LDD0241 | [1] | |
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DBIA Probe Info |
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C438(2.41) | LDD3312 | [2] | |
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IA-alkyne Probe Info |
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C627(0.00); C386(0.00); C438(0.00); C833(0.00) | LDD0162 | [3] | |
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WYneN Probe Info |
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N.A. | LDD0021 | [4] | |
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W1 Probe Info |
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C517(0.00); C605(0.00) | LDD0236 | [1] | |
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MPP-AC Probe Info |
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N.A. | LDD0428 | [5] | |
Competitor(s) Related to This Target
References