General Information of Target

Target ID LDTP06646
Target Name CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 (ST3GAL2)
Gene Name ST3GAL2
Gene ID 6483
Synonyms
SIAT4B; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Alpha 2,3-ST 2; Beta-galactoside alpha-2,3-sialyltransferase 2; EC 2.4.3.4; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; EC 2.4.3.2; ST3Gal II; ST3GalII; ST3GalA.2; Sialyltransferase 4B; SIAT4-B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRL
SKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFK
SHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMN
QAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTY
APVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFG
ADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
Target Bioclass
Enzyme
Family
Glycosyltransferase 29 family
Subcellular location
Golgi apparatus, Golgi stack membrane
Function
A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser.
Uniprot ID
Q16842
Ensemble ID
ENST00000342907.3
HGNC ID
HGNC:10863

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C152(0.92)  LDD3323  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C149(1.12)  LDD1510  [2]
 LDCM0280  AC20 HEK-293T C149(0.95)  LDD1519  [2]
 LDCM0288  AC28 HEK-293T C149(1.16)  LDD1527  [2]
 LDCM0297  AC36 HEK-293T C149(1.15)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C149(1.01)  LDD1540  [2]
 LDCM0306  AC44 HEK-293T C149(1.12)  LDD1545  [2]
 LDCM0315  AC52 HEK-293T C149(1.10)  LDD1554  [2]
 LDCM0324  AC60 HEK-293T C149(1.15)  LDD1563  [2]
 LDCM0408  CL20 HEK-293T C149(1.11)  LDD1612  [2]
 LDCM0421  CL32 HEK-293T C149(1.05)  LDD1625  [2]
 LDCM0434  CL44 HEK-293T C149(1.00)  LDD1638  [2]
 LDCM0447  CL56 HEK-293T C149(1.21)  LDD1650  [2]
 LDCM0460  CL68 HEK-293T C149(1.01)  LDD1663  [2]
 LDCM0473  CL8 HEK-293T C149(0.96)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C149(1.11)  LDD1677  [2]
 LDCM0487  CL92 HEK-293T C149(0.96)  LDD1690  [2]
 LDCM0022  KB02 A2780 C152(1.37)  LDD2254  [1]
 LDCM0023  KB03 A2780 C152(1.67)  LDD2671  [1]
 LDCM0024  KB05 SKMEL24 C152(0.92)  LDD3323  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402