Details of the Target

General Information of Target

Target ID LDTP06561
Target Name Vesicular acetylcholine transporter (SLC18A3)
Gene Name SLC18A3
Gene ID 6572
Synonyms
VACHT; Vesicular acetylcholine transporter; VAChT; Solute carrier family 18 member 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDY
IAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESE
DVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFA
ARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAG
KRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTT
CNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYG
ALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSV
YAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRS
ERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
Target Type
Discontinued
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Vesicular transporter family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin.
TTD ID
T89772
Uniprot ID
Q16572
DrugMap ID
TTV8KWS
Ensemble ID
ENST00000374115.5
HGNC ID
HGNC:10936
ChEMBL ID
CHEMBL4767

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		6.68  LDD0318  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 167 (CCDC167) . Q9P0B6

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminobenzovesamicol Small molecular drug D0N8WR
Vesamicol Small molecular drug D0I1QF
[123i]Iodobenzovesamicol Small molecular drug D09AWB
[3h]Vesamicol Small molecular drug D07EMU
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
T-588 Small molecular drug D03NZM

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580