Details of the Target

General Information of Target

Target ID LDTP06420
Target Name Transforming growth factor-beta-induced protein ig-h3 (TGFBI)
Gene Name TGFBI
Gene ID 7045
Synonyms
BIGH3; Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALFVRLLALALALALGPAATLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRK
YFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQL
YTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRV
LTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTIT
NNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDP
EALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILAT
NGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVF
KDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIA
AHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVF
APTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVS
LKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQERGDELADSALEIFKQASAF
SRASQRSVRLAPVYQKLLERMKH
Target Bioclass
Other
Subcellular location
Secreted
Function Plays a role in cell adhesion. May play a role in cell-collagen interactions.
Uniprot ID
Q15582
Ensemble ID
ENST00000442011.7
HGNC ID
HGNC:11771
ChEMBL ID
CHEMBL4295829

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K53(1.29); K676(3.40)  LDD3494  [1]
DBIA
 Probe Info  		C49(3.02)  LDD3310  [2]
BTD
 Probe Info  		C49(0.48)  LDD2091  [3]
CY-1
 Probe Info  		D561(0.00); K563(0.00)  LDD0246  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C65(1.22)  LDD2117  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C49(0.45)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C49(0.74)  LDD2131  [3]
 LDCM0545  Acetamide MDA-MB-231 C49(0.44)  LDD2138  [3]
 LDCM0498  BS-3668 MDA-MB-231 C49(0.48)  LDD2091  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C65(2.09)  LDD1702  [3]
 LDCM0022  KB02 769-P C97(0.87)  LDD2246  [2]
 LDCM0023  KB03 MDA-MB-231 C65(4.12)  LDD1701  [3]
 LDCM0024  KB05 COLO792 C49(3.02)  LDD3310  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C49(0.74); C65(1.09)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C65(0.99)  LDD2107  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C65(1.40)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C65(0.94)  LDD2125  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C49(0.85)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C65(1.79)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C65(1.04)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C65(1.02)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C65(2.20)  LDD2144  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C49(0.67)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Integrin beta-2 (ITGB2) Integrin beta chain family P05107
Protein S100-P (S100P) S-100 family P25815
Periostin (POSTN) . Q15063
Transforming growth factor-beta-induced protein ig-h3 (TGFBI) . Q15582

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255