Details of the Target

General Information of Target

Target ID LDTP06009
Target Name High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A)
Gene Name PDE7A
Gene ID 5150
Synonyms
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A; EC 3.1.4.53; HCP1; TM22; cAMP-specific phosphodiesterase 7A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
Target Type
Discontinued
Target Bioclass
Enzyme
Family
Cyclic nucleotide phosphodiesterase family, PDE7 subfamily
Subcellular location
Cytoplasm; Cytoplasm, cytosol
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
TTD ID
T39523
Uniprot ID
Q13946
DrugMap ID
TT1BC3A
Ensemble ID
ENST00000379419.8
HGNC ID
HGNC:8791
ChEMBL ID
CHEMBL3012

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS123 SNV: p.Q143K .
MELJUSO SNV: p.C38W .
MEWO Substitution: p.P400V .
NCIH2286 SNV: p.R110M .
OCUG1 SNV: p.R91P .
PEO1 SNV: p.T59I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C402(1.06)  LDD1492  [1]
IA-alkyne
 Probe Info  		C343(0.00); C402(0.00)  LDD0167  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C38(0.97)  LDD1513  [1]
 LDCM0283  AC23 HEK-293T C38(0.96)  LDD1522  [1]
 LDCM0292  AC31 HEK-293T C38(0.95)  LDD1531  [1]
 LDCM0300  AC39 HEK-293T C38(1.02)  LDD1539  [1]
 LDCM0309  AC47 HEK-293T C38(0.92)  LDD1548  [1]
 LDCM0318  AC55 HEK-293T C38(1.02)  LDD1557  [1]
 LDCM0327  AC63 HEK-293T C38(0.79)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C38(0.96)  LDD1568  [1]
 LDCM0379  CL11 HEK-293T C38(1.25)  LDD1583  [1]
 LDCM0411  CL23 HEK-293T C38(1.07)  LDD1615  [1]
 LDCM0424  CL35 HEK-293T C38(1.13)  LDD1628  [1]
 LDCM0437  CL47 HEK-293T C38(1.17)  LDD1641  [1]
 LDCM0450  CL59 HEK-293T C38(1.31)  LDD1653  [1]
 LDCM0464  CL71 HEK-293T C38(0.99)  LDD1667  [1]
 LDCM0477  CL83 HEK-293T C38(0.87)  LDD1680  [1]
 LDCM0490  CL95 HEK-293T C38(0.86)  LDD1693  [1]
 LDCM0022  KB02 HEK-293T C402(1.06)  LDD1492  [1]
 LDCM0023  KB03 HEK-293T C402(0.90)  LDD1497  [1]
 LDCM0024  KB05 HEK-293T C402(1.06)  LDD1502  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Caffeine Small molecular drug DB00201
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-isobutyl-1-methyl-7h-xanthine Small molecular drug DB07954
Trapidil Small molecular drug DB09283
3-(26-difluorophenyl)-2-(Methylthio)Quinazolin-4(3h)-one . DB08602
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-3557156 . D0PZ4Y

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019