Details of the Target

General Information of Target

Target ID LDTP05672
Target Name Contactin-1 (CNTN1)
Gene Name CNTN1
Gene ID 1272
Synonyms
Contactin-1; Glycoprotein gp135; Neural cell surface protein F3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGK
VSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNY
GMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVF
ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPY
PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNI
QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP
TIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM
KKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGG
IYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW
SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV
RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE
GNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRN
RELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAF
QVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESY
QIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFT
KKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKH
SIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF
Target Type
Literature-reported
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, Contactin family
Subcellular location
Lipid-anchor, GPI-anchor; Extracellular side; Cell membrane
Function
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
TTD ID
T58393
Uniprot ID
Q12860
DrugMap ID
TTPR8FK
Ensemble ID
ENST00000347616.5
HGNC ID
HGNC:2171

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.S914Ter .
AN3CA SNV: p.V259A .
CCK81 Insertion: p.N477KfsTer2 .
DOTC24510 SNV: p.D750N .
HCT15 SNV: p.L610M .
HT1197 Deletion: p.R377DfsTer5 .
IGR1 SNV: p.Y944C .
IGROV1 SNV: p.D167G .
IPC298 SNV: p.P137S .
JURKAT SNV: p.D563E .
KYSE410 SNV: p.E375Ter .
LNCaP clone FGC Insertion: p.P1000HfsTer24 .
MCC26 SNV: p.W754Ter .
NCIH1703 SNV: p.I392L; p.W454C .
NCIH2286 SNV: p.D205V .
NCIH23 SNV: p.Q841K .
NUGC3 SNV: p.V942A .
SNU449 SNV: p.R187Ter .
SW1271 SNV: p.E150Ter; p.S217F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.41  LDD0318  [1]
DBIA
 Probe Info  		C65(2.16)  LDD3433  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 GB-1 C65(4.90)  LDD2334  [2]
 LDCM0023  KB03 DAN-G C65(1.58)  LDD2730  [2]
 LDCM0024  KB05 SK-N-AS C65(2.16)  LDD3433  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1) Protein-tyrosine phosphatase family P23471
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Contactin-associated protein-like 2 (CNTNAP2) Neurexin family Q9UHC6

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060