Details of the Target | Chem(Pro)²

General Information of Target

Target ID	LDTP05608
Target Name	Leiomodin-3 (LMOD3)
Gene Name	LMOD3
Gene ID	56203
Synonyms	Leiomodin-3; Leiomodin, fetal form
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDK PPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLK EKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQ IRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTD LDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAF ALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEI ARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAML ENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRT DPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLN DIRHSSVAYLKPVQLPKELA
Target Bioclass	Other
Family	Tropomodulin family
Subcellular location	Cytoplasm
Function	Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization.
Uniprot ID	Q0VAK6
Ensemble ID	ENST00000420581.7
HGNC ID	HGNC:6649

Target Site Mutations in Different Cell Lines

Cell line	Mutation details			Probe for labeling this protein in this cell
CAL51	SNV: p.E151Ter			.
HCT15	SNV: p.G293C			.
JURKAT	SNV: p.R202I			.
KYM1	SNV: p.A290T			.
NCIH661	SNV: p.P428L			.
REH	SNV: p.S545N			.
SNGM	Deletion: p.L228Ter			.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
CY4 Probe Info			Q206(0.00); Q208(0.00)	LDD0247	[1]

References

1	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.