Details of the Target
General Information of Target
| Target ID | LDTP05505 | |||||
|---|---|---|---|---|---|---|
| Target Name | Transcription factor SOX-4 (SOX4) |
|
||||
| Gene Name | SOX4 | |||||
| Gene ID | 6659 | |||||
| Synonyms |
Transcription factor SOX-4 |
|||||
| 3D Structure | ||||||
| Sequence |
MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIK
RPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHM ADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGG GGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAE QAGAAALLPLGAAADHHSLYKARTPSASASASSAASASAALAAPGKHLAEKKVKRVYLFG GLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPSLSGRSSAASSPAAGRSPADHRG YASLRAASPAPSSAPSHASSSASSHSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLG SFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY |
|||||
| Target Bioclass |
Transcription factor
|
|||||
| Subcellular location |
Nucleus
|
|||||
| Function |
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression. Involved in skeletal myoblast differentiation by promoting gene expression of CALD1.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
TG42 Probe Info |
 |
4.82 | LDD0043 | [1] | |
|
DBIA Probe Info |
 |
C52(2.06) | LDD3364 | [2] | |
|
4-Iodoacetamidophenylacetylene Probe Info |
 |
N.A. | LDD0038 | [3] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0036 | [3] | |
|
Lodoacetamide azide Probe Info |
 |
N.A. | LDD0037 | [3] | |
|
Phosphinate-6 Probe Info |
 |
N.A. | LDD0018 | [4] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References