Details of the Target

General Information of Target

Target ID LDTP05332
Target Name Myocyte-specific enhancer factor 2B (MEF2B)
Gene Name MEF2B
Gene ID 100271849
Synonyms
XMEF2; Myocyte-specific enhancer factor 2B; RSRFR2; Serum response factor-like protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSANRLFQYAST
DMDRVLLKYTEYSEPHESRTNTDILETLKRRGIGLDGPELEPDEGPEEPGEKFRRLAGEG
GDPALPRPRLYPAAPAMPSPDVVYGALPPPGCDPSGLGEALPAQSRPSPFRPAAPKAGPP
GLVHPLFSPSHLTSKTPPPLYLPTEGRRSDLPGGLAGPRGGLNTSRSLYSGLQNPCSTAT
PGPPLGSFPFLPGGPPVGAEAWARRVPQPAAPPRRPPQSASSLSASLRPPGAPATFLRPS
PIPCSSPGPWQSLCGLGPPCAGCPWPTAGPGRRSPGGTSPERSPGTARARGDPTSLQASS
EKTQQ
Target Bioclass
Transcription factor
Family
MEF2 family
Subcellular location
Nucleus
Function
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.
Uniprot ID
Q02080
Ensemble ID
ENST00000424583.7
HGNC ID
HGNC:6995

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C152(1.72)  LDD2182  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C152(1.11)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C152(0.34)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C152(6.98)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C152(0.22)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C152(0.49)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C152(0.49)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C152(0.29)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C152(0.41)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C152(0.85)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C152(0.70)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C152(1.31)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C152(0.49)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C152(0.66)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C152(0.47)  LDD2201  [1]
 LDCM0468  Fragment33 Ramos C152(0.45)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C152(0.49)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C152(1.05)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C152(0.74)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C152(0.32)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C152(1.21)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C152(0.42)  LDD2188  [1]
 LDCM0022  KB02 Ramos C152(1.72)  LDD2182  [1]
 LDCM0023  KB03 Ramos C152(0.73)  LDD2183  [1]
 LDCM0024  KB05 Ramos C152(0.72)  LDD2185  [1]

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578