Details of the Target

General Information of Target

Target ID LDTP05281
Target Name CD83 antigen (CD83)
Gene Name CD83
Gene ID 9308
Synonyms
CD83 antigen; hCD83; B-cell activation protein; Cell surface protein HB15; CD antigen CD83
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKLLEGGEERM
ETPQEDHLRGQHYHQKGQNGSFDAPNERPYSLKIRNTTSCNSGTYRCTLQDPDGQRNLSG
KVILRVTGCPAQRKEETFKKYRAEIVLLLALVIFYLTLIIFTCKFARLQSIFPDFSKAGM
ERAFLPVTSPNKHLGLVTPHKTELV
Target Type
Literature-reported
Target Bioclass
Immunoglobulin
Subcellular location
Membrane
Function May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
TTD ID
T90800
Uniprot ID
Q01151
DrugMap ID
TTT9MRQ
Ensemble ID
ENST00000379153.4
HGNC ID
HGNC:1703

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C129(0.51)  LDD2136  [1]
IPM
 Probe Info  		C129(0.96)  LDD1701  [1]
DBIA
 Probe Info  		C100(1.09)  LDD1513  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C100(1.09)  LDD1513  [2]
 LDCM0283  AC23 HEK-293T C100(0.96)  LDD1522  [2]
 LDCM0292  AC31 HEK-293T C100(0.95)  LDD1531  [2]
 LDCM0300  AC39 HEK-293T C100(1.09)  LDD1539  [2]
 LDCM0309  AC47 HEK-293T C100(0.98)  LDD1548  [2]
 LDCM0318  AC55 HEK-293T C100(1.07)  LDD1557  [2]
 LDCM0327  AC63 HEK-293T C100(1.09)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C100(0.77)  LDD1568  [2]
 LDCM0379  CL11 HEK-293T C100(0.84)  LDD1583  [2]
 LDCM0411  CL23 HEK-293T C100(1.06)  LDD1615  [2]
 LDCM0424  CL35 HEK-293T C100(1.15)  LDD1628  [2]
 LDCM0437  CL47 HEK-293T C100(1.24)  LDD1641  [2]
 LDCM0450  CL59 HEK-293T C100(1.09)  LDD1653  [2]
 LDCM0464  CL71 HEK-293T C100(1.35)  LDD1667  [2]
 LDCM0477  CL83 HEK-293T C100(1.02)  LDD1680  [2]
 LDCM0490  CL95 HEK-293T C100(1.03)  LDD1693  [2]
 LDCM0023  KB03 MDA-MB-231 C129(0.96)  LDD1701  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C129(0.51)  LDD2136  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C129(0.32)  LDD2140  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402