Details of the Target
General Information of Target
| Target ID | LDTP05279 | |||||
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| Target Name | Sodium channel protein type 7 subunit alpha (SCN7A) |
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| Gene Name | SCN7A | |||||
| Gene ID | 6332 | |||||
| Synonyms |
SCN6A; Sodium channel protein type 7 subunit alpha; Atypical sodium channel Nav2.1; Nax channel; Sodium channel protein type VII subunit alpha |
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| 3D Structure | ||||||
| Sequence |
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG
MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS QI |
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| Target Bioclass |
Transporter and channel
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| Family |
Sodium channel (TC 1.A.1.10) family, SCN7A subfamily
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| Subcellular location |
Cell membrane
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| Function |
Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient. In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body. By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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IA-alkyne Probe Info |
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C471(3.56) | LDD2182 | [1] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0625 | F8 | Ramos | C471(1.70) | LDD2187 | [1] |
| LDCM0572 | Fragment10 | Ramos | C471(0.81) | LDD2189 | [1] |
| LDCM0574 | Fragment12 | Ramos | C471(0.42) | LDD2191 | [1] |
| LDCM0575 | Fragment13 | Ramos | C471(0.61) | LDD2192 | [1] |
| LDCM0576 | Fragment14 | Ramos | C471(1.04) | LDD2193 | [1] |
| LDCM0579 | Fragment20 | Ramos | C471(0.79) | LDD2194 | [1] |
| LDCM0580 | Fragment21 | Ramos | C471(0.62) | LDD2195 | [1] |
| LDCM0582 | Fragment23 | Ramos | C471(0.66) | LDD2196 | [1] |
| LDCM0578 | Fragment27 | Ramos | C471(0.55) | LDD2197 | [1] |
| LDCM0586 | Fragment28 | Ramos | C471(0.75) | LDD2198 | [1] |
| LDCM0588 | Fragment30 | Ramos | C471(0.55) | LDD2199 | [1] |
| LDCM0589 | Fragment31 | Ramos | C471(0.48) | LDD2200 | [1] |
| LDCM0590 | Fragment32 | Ramos | C471(0.80) | LDD2201 | [1] |
| LDCM0468 | Fragment33 | Ramos | C471(0.46) | LDD2202 | [1] |
| LDCM0596 | Fragment38 | Ramos | C471(0.41) | LDD2203 | [1] |
| LDCM0566 | Fragment4 | Ramos | C471(1.50) | LDD2184 | [1] |
| LDCM0610 | Fragment52 | Ramos | C471(0.59) | LDD2204 | [1] |
| LDCM0614 | Fragment56 | Ramos | C471(0.85) | LDD2205 | [1] |
| LDCM0569 | Fragment7 | Ramos | C471(1.21) | LDD2186 | [1] |
| LDCM0571 | Fragment9 | Ramos | C471(2.37) | LDD2188 | [1] |
| LDCM0022 | KB02 | Ramos | C471(3.56) | LDD2182 | [1] |
| LDCM0023 | KB03 | Ramos | C471(1.69) | LDD2183 | [1] |
| LDCM0024 | KB05 | Ramos | C471(1.57) | LDD2185 | [1] |