Details of the Target

General Information of Target

Target ID LDTP05250
Target Name Fanconi anemia group C protein (FANCC)
Gene Name FANCC
Gene ID 2176
Synonyms
FAC; FACC; Fanconi anemia group C protein; Protein FACC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQDSVDLSCDYQFWMQKLSVWDQASTLETQQDTCLHVAQFQEFLRKMYEALKEMDSNTV
IERFPTIGQLLAKACWNPFILAYDESQKILIWCLCCLINKEPQNSGQSKLNSWIQGVLSH
ILSALRFDKEVALFTQGLGYAPIDYYPGLLKNMVLSLASELRENHLNGFNTQRRMAPERV
ASLSRVCVPLITLTDVDPLVEALLICHGREPQEILQPEFFEAVNEAILLKKISLPMSAVV
CLWLRHLPSLEKAMLHLFEKLISSERNCLRRIECFIKDSSLPQAACHPAIFRVVDEMFRC
ALLETDGALEIIATIQVFTQCFVEALEKASKQLRFALKTYFPYTSPSLAMVLLQDPQDIP
RGHWLQTLKHISELLREAVEDQTHGSCGGPFESWFLFIHFGGWAEMVAEQLLMSAAEPPT
ALLWLLAFYYGPRDGRQQRAQTMVQVKAVLGHLLAMSRSSSLSAQDLQTVAGQGTDTDLR
APAQQLIRHLLLNFLLWAPGGHTIAWDVITLMAHTAEITHEIIGFLDQTLYRWNRLGIES
PRSEKLARELLKELRTQV
Target Bioclass
Other
Subcellular location
Nucleus
Function
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Uniprot ID
Q00597
Ensemble ID
ENST00000289081.8
HGNC ID
HGNC:3584

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C241(1.11)  LDD1509  [1]
N1
 Probe Info  		N.A.  LDD0245  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C241(1.11)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C300(1.06)  LDD1512  [1]
 LDCM0278  AC19 HEK-293T C241(0.88)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C300(1.14)  LDD1521  [1]
 LDCM0287  AC27 HEK-293T C241(0.71)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C241(1.05)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C300(1.09)  LDD1530  [1]
 LDCM0296  AC35 HEK-293T C241(0.87)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C300(1.16)  LDD1538  [1]
 LDCM0305  AC43 HEK-293T C241(0.95)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C300(1.14)  LDD1547  [1]
 LDCM0314  AC51 HEK-293T C241(0.96)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C300(1.20)  LDD1556  [1]
 LDCM0322  AC59 HEK-293T C241(1.20)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C300(1.12)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C300(1.46)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C300(1.21)  LDD1572  [1]
 LDCM0406  CL19 HEK-293T C241(0.84)  LDD1610  [1]
 LDCM0410  CL22 HEK-293T C300(1.37)  LDD1614  [1]
 LDCM0420  CL31 HEK-293T C241(1.01)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C300(0.92)  LDD1627  [1]
 LDCM0433  CL43 HEK-293T C241(0.92)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C300(1.16)  LDD1640  [1]
 LDCM0446  CL55 HEK-293T C241(1.10)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C300(1.05)  LDD1652  [1]
 LDCM0459  CL67 HEK-293T C241(0.79)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C241(1.19)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C300(0.99)  LDD1666  [1]
 LDCM0472  CL79 HEK-293T C241(0.89)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C300(1.03)  LDD1679  [1]
 LDCM0486  CL91 HEK-293T C241(0.81)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C300(1.07)  LDD1692  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmin (HSP90B1) Heat shock protein 90 family P14625

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.