Details of the Target

General Information of Target

Target ID	LDTP05162
Target Name	Protein delta homolog 1 (DLK1)
Gene Name	DLK1
Gene ID	8788
Synonyms	DLK; Protein delta homolog 1; DLK-1; pG2) [Cleaved into: Fetal antigen 1; FA1)]
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYS GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA VNIIFPEKIDMTTFSKEAGDEEI
Target Type	Clinical trial
Target Bioclass	Other
Subcellular location	Membrane
Function	May have a role in neuroendocrine differentiation.
TTD ID	T16738
Uniprot ID	P80370
DrugMap ID	TTF4AVB
Ensemble ID	ENST00000331224.10
HGNC ID	HGNC:2907
ChEMBL ID	CHEMBL5671

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
AN3CA	Deletion: p.P160LfsTer50	.
DU145	SNV: p.L64I	.
HCT15	SNV: p.P47H	.
HT115	SNV: p.R338H	.
Ishikawa (Heraklio) 02 ER	Insertion: p.G161WfsTer27	.
MDST8	SNV: p.D147N	.
MEWO	SNV: p.D108A; p.E331K	.
NCIH446	SNV: p.C37S	.
RVH421	SNV: p.N41D	.
SKMEL5	SNV: p.S136F	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
FBPP2 Probe Info			17.92	LDD0318	[1]

PAL-AfBPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
STS-2 Probe Info			N.A.	LDD0139	[2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1)				.	Q7Z699

The Drug(s) Related To This Target

Phase 1

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Gdc0134				.	D0Y1FU

References

1	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
2	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.