Details of the Target

General Information of Target

Target ID LDTP05086
Target Name SH3 domain-binding protein 2 (SH3BP2)
Gene Name SH3BP2
Gene ID 6452
Synonyms
3BP2; SH3 domain-binding protein 2; 3BP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHKRCVYY
FKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEEERKS
WMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPVDISLSPYPTDNEDYEHDDED
DSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPP
KHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRRMSDPPLSTMPTAPGLRKPPCFRES
ASPSPEPWTPGHGACSTSSAAIMATATSRNCDKLKSFHLSPRGPPTSEPPPVPANKPKFL
KIAEEDPPREAAMPGLFVPPVAPRPPALKLPVPEAMARPAVLPRPEKPQLPHLQRSPPDG
QSFRSFSFEKPRQPSQADTGGDDSDEDYEKVPLPNSVFVNTTESCEVERLFKATSPRGEP
QDGLYCIRNSSTKSGKVLVVWDETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHT
HVLPSHQSLLLRHPYGYTGPR
Target Bioclass
Other
Function
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Uniprot ID
P78314
Ensemble ID
ENST00000356331.9
HGNC ID
HGNC:10825

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.A112S DBIA    Probe Info 
HT1080 SNV: p.R292Q .
MEWO SNV: p.P310L DBIA    Probe Info 
NCIH1299 Substitution: p.H100R .
OVCAR5 SNV: p.D177E DBIA    Probe Info 
P31FUJ SNV: p.T540P DBIA    Probe Info 
REH SNV: p.P221S .
RL SNV: p.D442G .
RL952 SNV: p.R213K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C317(2.48)  LDD3314  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C465(1.00)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C465(0.94)  LDD1510  [3]
 LDCM0277  AC18 HEK-293T C465(1.41)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C465(0.92)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C465(0.93)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C465(1.27); C267(0.96)  LDD1520  [3]
 LDCM0286  AC26 HEK-293T C465(0.85)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C465(1.00)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C465(1.08); C267(0.89)  LDD1528  [3]
 LDCM0295  AC34 HEK-293T C465(1.10)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C465(0.82)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C465(1.35); C267(0.78)  LDD1537  [3]
 LDCM0301  AC4 HEK-293T C465(0.70)  LDD1540  [3]
 LDCM0304  AC42 HEK-293T C465(1.27)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C465(1.04)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C465(0.85); C267(1.04)  LDD1546  [3]
 LDCM0312  AC5 HEK-293T C465(1.21); C267(1.38)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C465(1.55)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C465(0.80)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C465(1.14); C267(0.90)  LDD1555  [3]
 LDCM0321  AC58 HEK-293T C465(1.03)  LDD1560  [3]
 LDCM0324  AC60 HEK-293T C465(1.27)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C465(1.15); C267(1.14)  LDD1564  [3]
 LDCM0248  AKOS034007472 HEK-293T C465(1.25); C267(0.93)  LDD1511  [3]
 LDCM0367  CL1 HEK-293T C465(0.86)  LDD1571  [3]
 LDCM0370  CL101 HEK-293T C465(1.07)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C465(0.92)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C465(1.26)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C465(1.06)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C465(1.15)  LDD1591  [3]
 LDCM0392  CL121 HEK-293T C465(1.29)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C465(1.00)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C465(0.84)  LDD1604  [3]
 LDCM0405  CL18 HEK-293T C465(1.45)  LDD1609  [3]
 LDCM0408  CL20 HEK-293T C465(0.73)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C465(0.91); C267(1.09)  LDD1613  [3]
 LDCM0413  CL25 HEK-293T C465(1.00)  LDD1617  [3]
 LDCM0419  CL30 HEK-293T C465(1.06)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C465(0.93)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C465(0.89); C267(0.91)  LDD1626  [3]
 LDCM0426  CL37 HEK-293T C465(0.98)  LDD1630  [3]
 LDCM0432  CL42 HEK-293T C465(0.92)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C465(0.67)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C465(1.16); C267(1.07)  LDD1639  [3]
 LDCM0439  CL49 HEK-293T C465(1.14)  LDD1643  [3]
 LDCM0445  CL54 HEK-293T C465(0.74)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C465(0.78)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C465(1.08); C267(1.11)  LDD1651  [3]
 LDCM0451  CL6 HEK-293T C465(0.77)  LDD1654  [3]
 LDCM0453  CL61 HEK-293T C465(1.04)  LDD1656  [3]
 LDCM0458  CL66 HEK-293T C465(0.80)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C465(0.97)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C465(0.94); C267(0.95)  LDD1664  [3]
 LDCM0466  CL73 HEK-293T C465(1.22)  LDD1669  [3]
 LDCM0471  CL78 HEK-293T C465(1.13)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C465(0.87)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C465(1.12)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C465(1.19); C267(1.02)  LDD1678  [3]
 LDCM0479  CL85 HEK-293T C465(1.09)  LDD1682  [3]
 LDCM0484  CL9 HEK-293T C465(0.92); C267(1.05)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C465(0.65)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C465(0.93)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C465(1.01); C267(1.21)  LDD1691  [3]
 LDCM0492  CL97 HEK-293T C465(1.07)  LDD1695  [3]
 LDCM0022  KB02 786-O C324(2.27)  LDD2247  [1]
 LDCM0023  KB03 786-O C324(1.89)  LDD2664  [1]
 LDCM0024  KB05 IGR37 C317(2.48)  LDD3314  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402