Details of the Target

General Information of Target

Target ID LDTP04985
Target Name Thymosin beta-4 (TMSB4X)
Gene Name TMSB4X
Gene ID 7114
Synonyms
TB4X; THYB4; TMSB4; Thymosin beta-4; T beta-4; Fx) [Cleaved into: Hemoregulatory peptide AcSDKP; Ac-Ser-Asp-Lys-Pro; N-acetyl-SDKP; AcSDKP; Seraspenide)]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Target Type
Literature-reported
Target Bioclass
Other
Family
Thymosin beta family
Subcellular location
Cytoplasm, cytoskeleton
Function
Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.; [Hemoregulatory peptide AcSDKP]: Potent inhibitor of bone marrow derived stem cell differentiation. Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
TTD ID
T85005
Uniprot ID
P62328
DrugMap ID
TTMVAIU
Ensemble ID
ENST00000380633.1
HGNC ID
HGNC:11881

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		N.A.  LDD0246  [1]
ATP probe
 Probe Info  		K12(0.00); K32(0.00)  LDD0035  [2]
AZ-9
 Probe Info  		N.A.  LDD0395  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.