Details of the Target

General Information of Target

Target ID LDTP04891
Target Name Ras-related protein Rab-4B (RAB4B)
Gene Name RAB4B
Gene ID 53916
Synonyms
Ras-related protein Rab-4B; EC 3.6.5.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQ
IWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCG
NKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDP
ERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cell membrane
Function
Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Protein transport. Probably involved in vesicular traffic. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets.
Uniprot ID
P61018
Ensemble ID
ENST00000357052.8
HGNC ID
HGNC:9782

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.E68Q .
SNGM SNV: p.A82T .
SUPT1 SNV: p.T64M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y189(5.01)  LDD0260  [1]
DBIA
 Probe Info  		C58(1.65)  LDD3314  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C23(0.00); C119(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C23(0.00); C119(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C119(0.00); C23(0.00)  LDD0037  [3]
NAIA_5
 Probe Info  		C23(0.00); C119(0.00)  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C23(1.05)  LDD1510  [5]
 LDCM0280  AC20 HEK-293T C23(1.18)  LDD1519  [5]
 LDCM0288  AC28 HEK-293T C23(1.07)  LDD1527  [5]
 LDCM0297  AC36 HEK-293T C23(0.99)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C23(1.10)  LDD1540  [5]
 LDCM0306  AC44 HEK-293T C23(1.12)  LDD1545  [5]
 LDCM0315  AC52 HEK-293T C23(1.12)  LDD1554  [5]
 LDCM0324  AC60 HEK-293T C23(1.00)  LDD1563  [5]
 LDCM0367  CL1 HEK-293T C23(0.90)  LDD1571  [5]
 LDCM0370  CL101 HEK-293T C23(0.98)  LDD1574  [5]
 LDCM0374  CL105 HEK-293T C23(1.06)  LDD1578  [5]
 LDCM0378  CL109 HEK-293T C23(1.06)  LDD1582  [5]
 LDCM0383  CL113 HEK-293T C23(0.91)  LDD1587  [5]
 LDCM0387  CL117 HEK-293T C23(1.03)  LDD1591  [5]
 LDCM0392  CL121 HEK-293T C23(1.06)  LDD1596  [5]
 LDCM0396  CL125 HEK-293T C23(1.04)  LDD1600  [5]
 LDCM0400  CL13 HEK-293T C23(0.93)  LDD1604  [5]
 LDCM0408  CL20 HEK-293T C23(1.08)  LDD1612  [5]
 LDCM0413  CL25 HEK-293T C23(1.05)  LDD1617  [5]
 LDCM0421  CL32 HEK-293T C23(1.03)  LDD1625  [5]
 LDCM0426  CL37 HEK-293T C23(1.00)  LDD1630  [5]
 LDCM0434  CL44 HEK-293T C23(1.12)  LDD1638  [5]
 LDCM0439  CL49 HEK-293T C23(1.09)  LDD1643  [5]
 LDCM0447  CL56 HEK-293T C23(1.12)  LDD1650  [5]
 LDCM0453  CL61 HEK-293T C23(0.87)  LDD1656  [5]
 LDCM0460  CL68 HEK-293T C23(1.13)  LDD1663  [5]
 LDCM0466  CL73 HEK-293T C23(0.97)  LDD1669  [5]
 LDCM0473  CL8 HEK-293T C23(1.05)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C23(1.11)  LDD1677  [5]
 LDCM0479  CL85 HEK-293T C23(0.97)  LDD1682  [5]
 LDCM0487  CL92 HEK-293T C23(0.93)  LDD1690  [5]
 LDCM0492  CL97 HEK-293T C23(0.94)  LDD1695  [5]
 LDCM0625  F8 Ramos C23(0.95); C119(0.48)  LDD2187  [6]
 LDCM0572  Fragment10 Ramos C23(0.41)  LDD2189  [6]
 LDCM0573  Fragment11 Ramos C119(6.84)  LDD2190  [6]
 LDCM0574  Fragment12 Ramos C23(0.45)  LDD2191  [6]
 LDCM0576  Fragment14 Ramos C119(1.24)  LDD2193  [6]
 LDCM0579  Fragment20 Ramos C23(0.29)  LDD2194  [6]
 LDCM0580  Fragment21 Ramos C23(0.59)  LDD2195  [6]
 LDCM0586  Fragment28 Ramos C23(0.48)  LDD2198  [6]
 LDCM0588  Fragment30 Ramos C23(0.73)  LDD2199  [6]
 LDCM0468  Fragment33 Ramos C23(0.36)  LDD2202  [6]
 LDCM0566  Fragment4 Ramos C23(0.92); C119(0.65)  LDD2184  [6]
 LDCM0569  Fragment7 Ramos C23(0.90); C119(0.43)  LDD2186  [6]
 LDCM0571  Fragment9 Ramos C23(0.43)  LDD2188  [6]
 LDCM0022  KB02 Ramos C119(0.29)  LDD2182  [6]
 LDCM0023  KB03 Ramos C23(1.00); C119(0.42)  LDD2183  [6]
 LDCM0024  KB05 IGR37 C58(1.65)  LDD3314  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division control protein 45 homolog (CDC45) CDC45 family O75419
Golgi-associated RAB2 interactor protein 6 (GARIN6) GARIN family Q8NEG0
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578