Details of the Target

General Information of Target

Target ID LDTP04845
Target Name Anaphase-promoting complex subunit 15 (ANAPC15)
Gene Name ANAPC15
Gene ID 25906
Synonyms
C11orf51; Anaphase-promoting complex subunit 15; APC15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASE
HYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWM
I
Target Bioclass
Other
Family
APC15 family
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
Uniprot ID
P60006
Ensemble ID
ENST00000227618.9
HGNC ID
HGNC:24531

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HGC27 SNV: p.D69H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C24(20.00)  LDD1708  [1]
DBIA
 Probe Info  		C24(1.27)  LDD1507  [2]
Compound 11
 Probe Info  		N.A.  LDD2213  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C24(1.27)  LDD1507  [2]
 LDCM0270  AC15 HEK-293T C24(1.55)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C24(1.74)  LDD1515  [2]
 LDCM0283  AC23 HEK-293T C24(1.83)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C24(1.23)  LDD1524  [2]
 LDCM0292  AC31 HEK-293T C24(0.87)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C24(1.78)  LDD1533  [2]
 LDCM0300  AC39 HEK-293T C24(1.94)  LDD1539  [2]
 LDCM0303  AC41 HEK-293T C24(1.98)  LDD1542  [2]
 LDCM0309  AC47 HEK-293T C24(1.31)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C24(1.53)  LDD1550  [2]
 LDCM0318  AC55 HEK-293T C24(1.71)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C24(1.22)  LDD1559  [2]
 LDCM0327  AC63 HEK-293T C24(1.34)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C24(0.71)  LDD1568  [2]
 LDCM0356  AKOS034007680 HEK-293T C24(1.48)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C24(1.05)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C24(1.12)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C24(1.79)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C24(0.87)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C24(0.96)  LDD1583  [2]
 LDCM0383  CL113 HEK-293T C24(1.07)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C24(1.21)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C24(1.66)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C24(0.93)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C24(1.64)  LDD1604  [2]
 LDCM0404  CL17 HEK-293T C24(1.96)  LDD1608  [2]
 LDCM0411  CL23 HEK-293T C24(2.07)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C24(1.93)  LDD1617  [2]
 LDCM0417  CL29 HEK-293T C24(1.69)  LDD1621  [2]
 LDCM0424  CL35 HEK-293T C24(1.45)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C24(2.15)  LDD1630  [2]
 LDCM0431  CL41 HEK-293T C24(1.65)  LDD1635  [2]
 LDCM0437  CL47 HEK-293T C24(1.37)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C24(1.03)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C24(1.21)  LDD1644  [2]
 LDCM0444  CL53 HEK-293T C24(1.66)  LDD1647  [2]
 LDCM0450  CL59 HEK-293T C24(1.29)  LDD1653  [2]
 LDCM0453  CL61 HEK-293T C24(2.02)  LDD1656  [2]
 LDCM0457  CL65 HEK-293T C24(2.31)  LDD1660  [2]
 LDCM0464  CL71 HEK-293T C24(1.64)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C24(1.00)  LDD1669  [2]
 LDCM0470  CL77 HEK-293T C24(1.63)  LDD1673  [2]
 LDCM0477  CL83 HEK-293T C24(1.05)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C24(1.60)  LDD1682  [2]
 LDCM0483  CL89 HEK-293T C24(1.96)  LDD1686  [2]
 LDCM0490  CL95 HEK-293T C24(3.21)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C24(1.49)  LDD1695  [2]
 LDCM0022  KB02 T cell-activated C24(20.00)  LDD1708  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279