Details of the Target
General Information of Target
| Target ID | LDTP04759 | |||||
|---|---|---|---|---|---|---|
| Target Name | Neurotrypsin (PRSS12) | |||||
| Gene Name | PRSS12 | |||||
| Gene ID | 8492 | |||||
| Synonyms |
Neurotrypsin; EC 3.4.21.-; Leydin; Motopsin; Serine protease 12 |
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| 3D Structure | ||||||
| Sequence |
MTLARFVLALMLGALPEVVGFDSVLNDSLHHSHRHSPPAGPHYPYYLPTQQRPPRTRPPP
PLPRFPRPPRALPAQRPHALQAGHTPRPHPWGCPAGEPWVSVTDFGAPCLRWAEVPPFLE RSPPASWAQLRGQRHNFCRSPDGAGRPWCFYGDARGKVDWGYCDCRHGSVRLRGGKNEFE GTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCR GDEENILLCEKDIWQGGVCPQKMAAAVTCSFSHGPTFPIIRLAGGSSVHEGRVELYHAGQ WGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQCP KSSWGEHNCGHKEDAGVSCTPLTDGVIRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELN TYVVCRQLGFKYGKQASANHFEESTGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHRED VSIACYPGGEGHRLSLGFPVRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQ LGYKGPARARTMAYFGEGKGPIHVDNVKCTGNERSLADCIKQDIGRHNCRHSEDAGVICD YFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLL CGATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRP DRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDTGRAYSRT LQQAAIPLLPKRFCEERYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVV YGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Peptidase S1 family
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| Subcellular location |
Secreted
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| Function | Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
FBPP2 Probe Info |
 |
2.14 | LDD0318 | [1] | |
|
DBIA Probe Info |
 |
C259(2.80) | LDD3345 | [2] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0036 | [3] | |
Competitor(s) Related to This Target
References