Details of the Target

General Information of Target

Target ID LDTP04539
Target Name Diacylglycerol kinase theta (DGKQ)
Gene Name DGKQ
Gene ID 1609
Synonyms
DAGK4; Diacylglycerol kinase theta; DAG kinase theta; DGKtheta; EC 2.7.1.107; EC 2.7.1.93; Diglyceride kinase theta; DGK-theta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPG
HSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPV
AHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHD
THHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLR
SLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDGADGSAAVGPGRETQATPESGKQTL
KIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACDAW
AGGKAGSAVISEEGRSPGSGEATPEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVRVTPK
STARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVR
QVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQG
AVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGL
KGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEET
RYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLD
AHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYV
RVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKP
RMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGH
MIISAAGPKVHMLRKAKQKPRRAGTTRDARADAAPAPESDPR
Target Bioclass
Enzyme
Family
Eukaryotic diacylglycerol kinase family
Subcellular location
Cytoplasm
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis.
Uniprot ID
P52824
Ensemble ID
ENST00000273814.8
HGNC ID
HGNC:2856

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C607(2.08); C108(2.97); C123(1.58)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C607(0.84)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C607(1.04)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C108(1.11)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C607(1.07)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C607(0.99)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C607(1.13)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C108(0.85)  LDD1519  [2]
 LDCM0285  AC25 HEK-293T C607(1.13)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C607(0.89)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C108(0.91)  LDD1527  [2]
 LDCM0294  AC33 HEK-293T C607(1.04)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C607(1.01)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C108(0.87)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C108(0.88)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C607(1.10)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C607(0.95)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C108(0.95)  LDD1545  [2]
 LDCM0311  AC49 HEK-293T C607(1.13)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C607(1.08)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C108(0.79)  LDD1554  [2]
 LDCM0320  AC57 HEK-293T C607(0.95)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C607(1.63)  LDD1560  [2]
 LDCM0324  AC60 HEK-293T C108(0.97)  LDD1563  [2]
 LDCM0356  AKOS034007680 HEK-293T C607(1.00)  LDD1570  [2]
 LDCM0371  CL102 HEK-293T C607(1.06)  LDD1575  [2]
 LDCM0375  CL106 HEK-293T C607(1.46)  LDD1579  [2]
 LDCM0380  CL110 HEK-293T C607(0.93)  LDD1584  [2]
 LDCM0384  CL114 HEK-293T C607(1.19)  LDD1588  [2]
 LDCM0388  CL118 HEK-293T C607(1.11)  LDD1592  [2]
 LDCM0393  CL122 HEK-293T C607(1.01)  LDD1597  [2]
 LDCM0397  CL126 HEK-293T C607(0.87)  LDD1601  [2]
 LDCM0401  CL14 HEK-293T C607(1.16)  LDD1605  [2]
 LDCM0404  CL17 HEK-293T C607(0.88)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C607(1.09)  LDD1609  [2]
 LDCM0407  CL2 HEK-293T C607(1.51)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C108(0.88)  LDD1612  [2]
 LDCM0414  CL26 HEK-293T C607(0.81)  LDD1618  [2]
 LDCM0417  CL29 HEK-293T C607(1.04)  LDD1621  [2]
 LDCM0419  CL30 HEK-293T C607(0.88)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C108(0.88)  LDD1625  [2]
 LDCM0431  CL41 HEK-293T C607(1.01)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C607(0.96)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C108(0.80)  LDD1638  [2]
 LDCM0440  CL5 HEK-293T C607(0.81)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C607(1.46)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C607(1.38)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C607(0.75)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C108(0.91)  LDD1650  [2]
 LDCM0451  CL6 HEK-293T C607(0.91)  LDD1654  [2]
 LDCM0454  CL62 HEK-293T C607(1.20)  LDD1657  [2]
 LDCM0457  CL65 HEK-293T C607(1.34)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C607(1.05)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C108(1.22)  LDD1663  [2]
 LDCM0467  CL74 HEK-293T C607(1.05)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C607(1.18)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C607(0.89)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C108(0.77)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C108(0.84)  LDD1677  [2]
 LDCM0480  CL86 HEK-293T C607(1.44)  LDD1683  [2]
 LDCM0483  CL89 HEK-293T C607(1.52)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C607(1.02)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C108(0.90)  LDD1690  [2]
 LDCM0493  CL98 HEK-293T C607(1.05)  LDD1696  [2]
 LDCM0427  Fragment51 HEK-293T C607(1.12)  LDD1631  [2]
 LDCM0022  KB02 786-O C607(1.90); C108(1.65)  LDD2247  [1]
 LDCM0023  KB03 786-O C607(1.95); C108(2.18)  LDD2664  [1]
 LDCM0024  KB05 IGR37 C607(2.08); C108(2.97); C123(1.58)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-tocopherol Succinate . DB14001

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402