Details of the Target

General Information of Target

Target ID LDTP04350
Target Name Sulfotransferase 1A2 (SULT1A2)
Gene Name SULT1A2
Gene ID 6799
Synonyms
STP2; Sulfotransferase 1A2; ST1A2; EC 2.8.2.1; Aryl sulfotransferase 2; Phenol sulfotransferase 2; Phenol-sulfating phenol sulfotransferase 2; P-PST 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELIQDISRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDM
IYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTLLD
QKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWW
ELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNY
TTVRREFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAKKMAGCSLSFRSEL
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family
Subcellular location
Cytoplasm
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.
Uniprot ID
P50226
Ensemble ID
ENST00000335715.9
HGNC ID
HGNC:11454
ChEMBL ID
CHEMBL1743292

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C293(1.77)  LDD3310  [1]
AHL-Pu-1
 Probe Info  		C287(2.18)  LDD0168  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C287(2.18)  LDD0168  [2]
 LDCM0022  KB02 769-P C293(1.74)  LDD2246  [1]
 LDCM0023  KB03 769-P C293(2.27)  LDD2663  [1]
 LDCM0024  KB05 COLO792 C293(1.77)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Apomorphine Small molecular drug DB00714
Ibrexafungerp Small molecular drug DB12471
Methyldopa Small molecular drug DB00968
Pindolol Small molecular drug DB00960
Ritodrine Small molecular drug DB00867
Terbutaline Small molecular drug DB00871
Thyroid Porcine . DB09100

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.