Details of the Target
General Information of Target
| Target ID | LDTP04322 | |||||
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| Target Name | Kallikrein-7 (KLK7) |
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| Gene Name | KLK7 | |||||
| Gene ID | 5650 | |||||
| Synonyms |
PRSS6; SCCE; Kallikrein-7; hK7; EC 3.4.21.117; Serine protease 6; Stratum corneum chymotryptic enzyme; hSCCE |
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| 3D Structure | ||||||
| Sequence |
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLV
NERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNS QARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVY KDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCK FTKWINDTMKKHR |
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| Target Type |
Patented-recorded
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| Target Bioclass |
Enzyme
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| Family |
Peptidase S1 family, Kallikrein subfamily
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| Subcellular location |
Secreted
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| Function |
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C36(2.01) | LDD3440 | [1] | |
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MPP-AC Probe Info |
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N.A. | LDD0428 | [2] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References