Details of the Target

General Information of Target

Target ID LDTP04214
Target Name Mannan-binding lectin serine protease 1 (MASP1)
Gene Name MASP1
Gene ID 5648
Synonyms
CRARF; CRARF1; PRSS5; Mannan-binding lectin serine protease 1; EC 3.4.21.-; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1; Mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL
YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS
DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT
CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV
PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE
CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP
TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW
MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL
GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL
HPQYDPNTFENDVALVELLESPVLNAFVMPICLPEGPQQEGAMVIVSGWGKQFLQRFPET
LMEIEIPIVDHSTCQKAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQW
YLVGTVSWGDDCGKKDRYGVYSYIHHNKDWIQRVTGVRN
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development.
Uniprot ID
P48740
Ensemble ID
ENST00000169293.10
HGNC ID
HGNC:6901
ChEMBL ID
CHEMBL4295768

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JHH7 SNV: p.A641V; p.G658R .
NCIH196 Substitution: p.V556E .
U87MG SNV: p.I485L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C260(0.99)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C260(0.99)  LDD1507  [1]
 LDCM0276  AC17 HEK-293T C260(1.09)  LDD1515  [1]
 LDCM0285  AC25 HEK-293T C260(1.13)  LDD1524  [1]
 LDCM0294  AC33 HEK-293T C260(1.02)  LDD1533  [1]
 LDCM0303  AC41 HEK-293T C260(1.08)  LDD1542  [1]
 LDCM0311  AC49 HEK-293T C260(0.93)  LDD1550  [1]
 LDCM0320  AC57 HEK-293T C260(1.06)  LDD1559  [1]
 LDCM0356  AKOS034007680 HEK-293T C260(1.07)  LDD1570  [1]
 LDCM0369  CL100 HEK-293T C260(1.10)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C260(1.12)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C260(1.06)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C260(1.05)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C260(1.16)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C260(1.18)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C260(1.06)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C260(1.22)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C260(1.01)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C260(1.08)  LDD1608  [1]
 LDCM0416  CL28 HEK-293T C260(1.16)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C260(1.01)  LDD1621  [1]
 LDCM0429  CL4 HEK-293T C260(1.17)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C260(1.02)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C260(0.89)  LDD1635  [1]
 LDCM0440  CL5 HEK-293T C260(1.00)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C260(1.08)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C260(0.90)  LDD1647  [1]
 LDCM0456  CL64 HEK-293T C260(1.03)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C260(1.11)  LDD1660  [1]
 LDCM0469  CL76 HEK-293T C260(1.08)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C260(1.07)  LDD1673  [1]
 LDCM0482  CL88 HEK-293T C260(1.12)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C260(1.02)  LDD1686  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402