Details of the Target

General Information of Target

Target ID LDTP04145
Target Name Xanthine dehydrogenase/oxidase (XDH)
Gene Name XDH
Gene ID 7498
Synonyms
XDHA; Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase; XD; EC 1.17.1.4; Xanthine oxidase; XO; EC 1.17.3.2; Xanthine oxidoreductase; XOR)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDR
LQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGI
VMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC
MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQAS
TLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFG
AACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD
LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA
FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKE
ELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD
PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRY
ENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDK
VTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL
KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKM
LGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR
HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR
LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL
EGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGA
LLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA
SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLG
YSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAF
VQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV
GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVT
GVPENCKPWSVRV
Target Type
Successful
Target Bioclass
Enzyme
Family
Xanthine dehydrogenase family
Subcellular location
Cytoplasm
Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
TTD ID
T40954
Uniprot ID
P47989
DrugMap ID
TTXVNKB
Ensemble ID
ENST00000379416.4
HGNC ID
HGNC:12805
ChEMBL ID
CHEMBL1929

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C889(1.93)  LDD2286  [1]
BTD
 Probe Info  		C1000(0.17)  LDD2145  [2]
IPM
 Probe Info  		C1000(4.05)  LDD1701  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CAL-27 C889(1.93)  LDD2286  [1]
 LDCM0023  KB03 MDA-MB-231 C1000(4.05)  LDD1701  [2]
 LDCM0024  KB05 BICR-22 C889(1.15)  LDD3100  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1000(0.17)  LDD2145  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 20 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aldesleukin BiotechDrug DB00041
Adenosine Small molecular drug DB00640
Allopurinol Small molecular drug D04KYY
Azathioprine Small molecular drug DB00993
Carvedilol Small molecular drug DB01136
Cisplatin Small molecular drug DB00515
Doxorubicin Small molecular drug DB00997
Favipiravir Small molecular drug DB12466
Febuxostat Small molecular drug D0A5SE
Flavin Adenine Dinucleotide Small molecular drug DB03147
Fosdenopterin Small molecular drug D07GTW
Isosorbide Mononitrate Small molecular drug DB01020
Levocarnitine Small molecular drug DB00583
Menadione Small molecular drug DB00170
Mercaptopurine Small molecular drug DB01033
Nadh Small molecular drug DB00157
Nitrofural Small molecular drug DB00336
Pyrazinamide Small molecular drug DB00339
Trifluoperazine Small molecular drug DB00831
Deferoxamine . DB00746
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Curcumin Small molecular drug D07SDQ
Oxypurinol Small molecular drug D08FWK
Phase 2
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baicalein Small molecular drug D00YEV
Topiroxostat Small molecular drug D0WK0P
Tmx-049 . D5BMY9
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lc-350189 . D0I5JM
Investigative
Click To Hide/Show 26 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,2,3,4,6-penta-o-galloyl-beta-d-glucose Small molecular drug D00QDR
1-(3-cyano-phenyl)-1h-pyrazole-4-carboxylic Acid Small molecular drug D0G8XL
2-chloro-6(Methylamino)Purine Small molecular drug D0D9OC
3,4'-(1h-1,2,4-triazole-3,5-diyl)Dipyridine Small molecular drug D0IW5C
3,5-bis(2-methylpyridin-4-yl)-1h-1,2,4-triazole Small molecular drug D0C9ZN
3,5-di(Pyridin-4-yl)-1h-1,2,4-triazole Small molecular drug D0ZC8K
3-o-methylquercetin Small molecular drug D0L9EF
Acacetin Small molecular drug D0NS1S
Amentoflavone Small molecular drug D06HRX
Chrysoeriol Small molecular drug D01FGM
Dihydrokaempferol Small molecular drug D0R4FM
Dioxo(Sulfanyl)Molybdenum Small molecular drug DB03328
Dioxothiomolybdenum(Vi) Ion Small molecular drug D02CWE
Eniluracil Small molecular drug DB03516
Flavin-adenine Dinucleotide Small molecular drug D00IMW
Fukugetin Small molecular drug D08NIT
Liquirtigenin Small molecular drug D0K4PY
Niraxostat Small molecular drug DB03841
Persicarin Small molecular drug D0E5IM
Robinetin Small molecular drug D07NAY
Scutellarein Small molecular drug D00LMG
Spermine Small molecular drug DB00127
Wogonin Small molecular drug D00MXS
Aom-0763 . D0Z2NY
Inosine . DB04335
Nc-2500 . D05KKF
Patented
Click To Hide/Show 35 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azaindole Derivative 3 Small molecular drug D0D6UT
Azaindole Derivative 4 Small molecular drug D0RK1R
Azaindole Derivative 5 Small molecular drug D00GMJ
Azaindole Derivative 6 Small molecular drug D0J5GS
Azaindole Derivative 7 Small molecular drug D02VYR
Azole Benzene Derivative 1 Small molecular drug D0VY5N
Azole Benzene Derivative 2 Small molecular drug D06XJG
Azole Benzene Derivative 3 Small molecular drug D0J3ZM
Azole Benzene Derivative 4 Small molecular drug D0XY7C
Fused Heterocyclic Compound 1 Small molecular drug D0SY6J
Fused Heterocyclic Compound 10 Small molecular drug D0RK3S
Fused Heterocyclic Compound 11 Small molecular drug D04BAQ
Fused Heterocyclic Compound 2 Small molecular drug D0AV1B
Fused Heterocyclic Compound 3 Small molecular drug D01FMW
Fused Heterocyclic Compound 4 Small molecular drug D03JDR
Fused Heterocyclic Compound 5 Small molecular drug D0DQ6C
Fused Heterocyclic Compound 6 Small molecular drug D0NS7W
Fused Heterocyclic Compound 7 Small molecular drug D0G9OT
Fused Heterocyclic Compound 8 Small molecular drug D0N0MV
Fused Heterocyclic Compound 9 Small molecular drug D08KAT
Pmid27841045-compound-129 Small molecular drug D0RN2X
Pmid27841045-compound-130 Small molecular drug D04IGE
Pmid27841045-compound-131 Small molecular drug D0GQ0V
Pmid27841045-compound-132 Small molecular drug D0B5QZ
Pmid27841045-compound-133 Small molecular drug D0AU8E
Pmid27841045-compound-134 Small molecular drug D0FM8Q
Pmid27841045-compound-135 Small molecular drug D0YX0S
Pmid27841045-compound-136 Small molecular drug D0QY4O
Pmid27841045-compound-137 Small molecular drug D07TTT
Pmid27841045-compound-143 Small molecular drug D0Z2IO
Pmid27841045-compound-144 Small molecular drug D0AJ5T
Pmid27841045-compound-145 Small molecular drug D0EZ5O
Pmid27841045-compound-155 Small molecular drug D0S0EM
Pmid27841045-compound-156 Small molecular drug D0J0JH
Pmid27841045-compound-157 Small molecular drug D0LX9F
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bof-4272 Small molecular drug D0B8SC
Y-700 Small molecular drug D0E4FM

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060