Details of the Target

General Information of Target

Target ID LDTP03963
Target Name Beta-centractin (ACTR1B)
Gene Name ACTR1B
Gene ID 10120
Synonyms
CTRN2; Beta-centractin; Actin-related protein 1B; ARP1B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGP
KAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKN
REKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSI
MRVDIAGRDVSRYLRLLLRKEGVDFHTSAEFEVVRTIKERACYLSINPQKDEALETEKVQ
YTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVVAFAIHKSDMDLRRTLFANIVL
SGGSTLFKGFGDRLLSEVKKLAPKDIKIKISAPQERLYSTWIGGSILASLDTFKKMWVSK
KEYEEDGSRAIHRKTF
Target Bioclass
Other
Family
Actin family, ARP1 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
Uniprot ID
P42025
Ensemble ID
ENST00000289228.7
HGNC ID
HGNC:168

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K329(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
Probe 1
 Probe Info  		Y241(10.00); Y363(9,186.03)  LDD3495  [3]
BTD
 Probe Info  		C222(1.88); C34(1.01)  LDD2135  [4]
IPM
 Probe Info  		C34(0.53)  LDD1701  [4]
HHS-465
 Probe Info  		Y223(9.10)  LDD2237  [5]
DBIA
 Probe Info  		C222(0.85)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
TFBX
 Probe Info  		C222(0.00); C34(0.00)  LDD0148  [8]
1c-yne
 Probe Info  		K96(0.00); K32(0.00)  LDD0228  [9]
AOyne
 Probe Info  		10.30  LDD0443  [10]
NAIA_5
 Probe Info  		C222(0.00); C34(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C284
 Probe Info  		24.59  LDD1954  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C222(0.85)  LDD0078  [6]
 LDCM0632  CL-Sc Hep-G2 C222(1.05)  LDD2227  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C222(2.06); C34(1.11)  LDD1702  [4]
 LDCM0625  F8 Ramos C34(1.23); C222(1.24)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C34(1.11); C222(0.78)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C34(0.04); C222(20.00)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C34(1.50); C222(0.78)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C34(0.79); C222(0.61)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C34(1.08); C222(1.08)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C34(1.69); C222(0.45)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C34(0.97); C222(0.70)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C34(1.81)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C34(1.03)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C34(1.64); C222(0.78)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C34(1.36); C222(1.24)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C34(0.92); C222(0.78)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C34(1.15); C222(1.06)  LDD2201  [13]
 LDCM0468  Fragment33 Ramos C34(0.83); C222(0.73)  LDD2202  [13]
 LDCM0596  Fragment38 Ramos C34(1.28); C222(0.71)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C34(1.76)  LDD2184  [13]
 LDCM0610  Fragment52 Ramos C34(1.10); C222(0.74)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C34(1.09); C222(1.31)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C34(0.91); C222(1.46)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C34(1.36); C222(0.65)  LDD2188  [13]
 LDCM0022  KB02 Ramos C34(0.68); C222(0.71)  LDD2182  [13]
 LDCM0023  KB03 MDA-MB-231 C34(0.53)  LDD1701  [4]
 LDCM0024  KB05 COLO792 C34(4.48)  LDD3310  [14]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C222(1.88); C34(1.01)  LDD2135  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C222(1.79)  LDD2144  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynactin subunit 1 (DCTN1) Dynactin 150 kDa subunit family Q14203

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840