Details of the Target

General Information of Target

Target ID LDTP03921
Target Name ETS translocation variant 5 (ETV5)
Gene Name ETV5
Gene ID 2119
Synonyms
ERM; ETS translocation variant 5; Ets-related protein ERM
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAE
AQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNY
CAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHS
LPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNR
PSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYC
VDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGP
PYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYD
KLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDT
LPLTHFEDSPAYLLDMDRCSSLPYAEGFAY
Target Bioclass
Transcription factor
Family
ETS family
Subcellular location
Nucleus
Function Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
Uniprot ID
P41161
Ensemble ID
ENST00000306376.10
HGNC ID
HGNC:3494

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T480A .
COLO829 SNV: p.Y445C .
DU145 SNV: p.G393C .
HCT15 SNV: p.P331S .
HT115 SNV: p.F73V .
MFE319 SNV: p.A175T .
SUPT1 Deletion: p.R195DfsTer12
SNV: p.R407H		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.73  LDD0403  [1]
DBIA
 Probe Info  		C300(1.42); C308(1.42)  LDD1093  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C300(1.42); C308(1.42)  LDD1093  [2]
 LDCM0215  AC10 PaTu 8988t C300(0.77); C308(0.77)  LDD1094  [2]
 LDCM0226  AC11 PaTu 8988t C300(0.81); C308(0.81)  LDD1105  [2]
 LDCM0237  AC12 PaTu 8988t C300(1.21); C308(1.21)  LDD1116  [2]
 LDCM0259  AC14 PaTu 8988t C300(1.69); C308(1.69)  LDD1138  [2]
 LDCM0270  AC15 PaTu 8988t C300(0.90); C308(0.90)  LDD1149  [2]
 LDCM0279  AC2 PaTu 8988t C300(1.87); C308(1.87)  LDD1158  [2]
 LDCM0290  AC3 PaTu 8988t C300(1.44); C308(1.44)  LDD1169  [2]
 LDCM0301  AC4 PaTu 8988t C300(1.42); C308(1.42)  LDD1180  [2]
 LDCM0308  AC46 PaTu 8988t C300(0.98); C308(0.98)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C300(1.37); C308(1.37)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C300(1.21); C308(1.21)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C300(1.10); C308(1.10)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C300(1.21); C308(1.21)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C300(1.89); C308(1.89)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C300(0.22); C308(0.22)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C300(0.99); C308(0.99)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C300(2.40); C308(2.40)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C300(1.73); C308(1.73)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C300(0.77); C308(0.77)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C300(1.19); C308(1.19)  LDD1198  [2]
 LDCM0323  AC6 PaTu 8988t C300(0.98); C308(0.98)  LDD1202  [2]
 LDCM0334  AC7 PaTu 8988t C300(0.59); C308(0.59)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C300(1.04); C308(1.04)  LDD1224  [2]
 LDCM0349  AC83 PaTu 8988t C300(0.82); C308(0.82)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C300(0.78); C308(0.78)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C300(0.57); C308(0.57)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C300(0.65); C308(0.65)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C300(0.65); C308(0.65)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C300(0.50); C308(0.50)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C300(0.54); C308(0.54)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C300(0.98); C308(0.98)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C300(0.85); C308(0.85)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C300(0.50); C308(0.50)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C300(0.69); C308(0.69)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C300(0.63); C308(0.63)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C300(0.69); C308(0.69)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C300(0.76); C308(0.76)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C300(0.50); C308(0.50)  LDD1243  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C300(1.53); C308(1.53)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C300(1.45); C308(1.45)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C300(0.81); C308(0.81)  LDD1154  [2]
 LDCM0156  Aniline NCI-H1299 11.73  LDD0403  [1]
 LDCM0369  CL100 PaTu 8988t C300(1.31); C308(1.31)  LDD1248  [2]
 LDCM0370  CL101 PaTu 8988t C300(1.14); C308(1.14)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C300(1.08); C308(1.08)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C300(1.22); C308(1.22)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C300(1.79); C308(1.79)  LDD1252  [2]
 LDCM0392  CL121 PaTu 8988t C300(2.26); C308(2.26)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C300(1.22); C308(1.22)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C300(0.99); C308(0.99)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C300(1.03); C308(1.03)  LDD1274  [2]
 LDCM0486  CL91 PaTu 8988t C300(1.01); C308(1.01)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C300(1.12); C308(1.12)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C300(1.09); C308(1.09)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C300(0.84); C308(0.84)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C300(3.34); C308(3.34)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C300(1.05); C308(1.05)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C300(0.97); C308(0.97)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C300(1.42); C308(1.42)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C300(1.33); C308(1.33)  LDD1373  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.