Details of the Target
General Information of Target
| Target ID | LDTP03879 | |||||
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| Target Name | L-dopachrome tautomerase (DCT) |
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| Gene Name | DCT | |||||
| Gene ID | 1638 | |||||
| Synonyms |
TYRP2; L-dopachrome tautomerase; DCT; DT; EC 5.3.3.12; L-dopachrome Delta-isomerase; Tyrosinase-related protein 2; TRP-2; TRP2 |
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| 3D Structure | ||||||
| Sequence |
MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQ
CTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCER KKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCS VYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESF ALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCN GTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGT LDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQE LAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTL VALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA |
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| Target Bioclass |
Enzyme
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| Family |
Tyrosinase family
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| Subcellular location |
Melanosome membrane
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| Function | Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CHL1 | SNV: p.N178S | . | |||
| DU145 | SNV: p.Q55K | . | |||
| ECC2 | SNV: p.C95Ter | . | |||
| KMCH1 | SNV: p.P124Q | . | |||
| KURAMOCHI | SNV: p.Q56R | . | |||
| MEWO | SNV: p.G57D | DBIA Probe Info | |||
| NCIH2286 | SNV: p.R233G | . | |||
| ONS76 | SNV: p.G236A | . | |||
| OVK18 | SNV: p.S281N | . | |||
| RKO | SNV: p.A401T | . | |||
| SNGM | Deletion: p.R27EfsTer4 | . | |||
| SW1271 | SNV: p.N105Y | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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DBIA Probe Info |
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C118(2.66); C61(2.95); C52(1.92) | LDD3332 | [1] | |
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AHL-Pu-1 Probe Info |
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C226(2.04) | LDD0170 | [2] | |
Competitor(s) Related to This Target
References